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Volunteer for a Research Study

The Department of Preventive Medicine conducts observational research studies and clinical trials.

Observational Research – studies that collect data and samples from patients in order to examine patterns of disease, risk factors and outcomes over a period of time.
Clinical Trials – studies that test whether a medical or behavioral treatment is safe and effective to use in a particular group of people.

Planning A Change Easily (PACE)

logoVirtually all smoking cessation interventions have been conducted on the small percentage of smokers who indicate a willingness to quit smoking. Much less well-studied are approaches for assisting the smokers who are not ready to quit smoking at the current time (ex., not in the next 30 days). There have been two different approaches towards increasing cessation rates in smokers not ready to quit. The first approach is Motivational Interviewing using “5Rs”as a foundation (Relevance, Risks, Rewards, Roadblocks, Repetition). The second approach combines behavioral/pharmacological rate reduction as an approach to produce reductions in tobacco use. The current National Cancer Institute funded (1R01CA193245-01A1) study examines the comparative effectiveness of Motivational Interviewing, Rate Reduction, and their combination in a large sample (N = 828) of smokers not ready to quit. This design allows us to evaluate the independent and additive effects of Motivational Interviewing and Rate Reduction on quit attempts and smoking cessation. The primary endpoint will be point prevalence at the 6-month post-intervention follow-up (12 months after randomization). A second aim is to determine the cost effectiveness (cost per quit smoker) of each of the interventions.


Fit & Quit Study


Ideally, there would be programs that do not require people to choose between quitting smoking and gaining 10 pounds (on average). We are developing just such a program! 

Participants will try one of 3 different weight management strategies. In addition, all participants will receive the same 6 session phone-based smoking cessation program and 6 months of Chantix at no cost. In addition to treatment at no cost, participants may earn up to $100 for completing all aspects of the study. For further information, please see:  Call today to see if you qualify—901-448-2000

Conditions Affecting Neurocognitive Development and Learning in Early Childhood


CANDLE is an observational cohort research study of the development of children from birth to age eleven. The CANDLE study has enrolled 1503 healthy pregnant women in Shelby County between 2006-2011. The study name "CANDLE" stands for Conditions Affecting Neurocognitive Development and Learning in Early Childhood. The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother’s prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development and health from birth to age eleven. CANDLE is currently conducting study visits with 8-11 year-olds in an effort to assess the association between stress, genetics, and environmental exposures on both cognitive development and lung health in middle childhood. Website:

Restore Study

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Do you have a total knee replacement? Would you like to lose weight and adopt a healthy lifestyle? You may be eligible to join a new research study if you are someone who: Has a single total knee replacement; Is between the ages of 18-70; Is overweight; In this two-year study, you will receive physical activity, nutrition, and weight loss coaching at no cost. For more information about RESTORE contact us at 901-448-1TKR (901-448-1857) or Visit for more information.

Valor Study: For Below The Knee Amputees

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You may be eligible to join the VALOR research study (Veteran Amputees Leading prOsthetic Research) if you are someone who: Has a single leg, below the knee amputation; Has actively used a prosthesis for at least a year; Can walk inside and outside with your prosthesis; Is 18-80 years of age. The VALOR study is currently enrolling both veterans & non-veterans. Participant benefits include: Physical Therapy at no cost; Up to $250 for participation; Half of the participants will also receive a micropressor-controlled prosthetic foot (at no cost) with fitting and training. Contact us at 901-44U-WALK (901-448-9255) or Visit for more information.

Valor Study: Ankle Foot Orthosis Brace

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You may be eligible to join a new research study if you: Have a lower-limb impairment requiring an AFO to walk safely; Currently wear a prescribed AFO; Are 18 – 80 years of age. The study is scheduled to begin enrollment spring 2019 and will be open to veterans, non-veterans, and active duty personnel. In this 6-month research study, ALL participants will receive a new pair of orthotic shoes and physical therapy at no cost, and up to $250 for participation. Half of the participants will also be fitted with and trained to use a powered AFO to determine if it may improve functional performance and walking safety. Contact us at 901-44U-WALK (901-448-9255) or Visit for more information.

Last Published: May 23, 2019