Khyobeni Mozhui, PhD

Education

• PhD Institution: UTHSC, Neuroscience (Neurogenetics)
• Undergraduate Institution: Delhi University, Biochemistry

Research Interests

My overarching research interest is to understand how multiple genetic, epigenetic, and environmental factors interact to define complex traits. Much of my research has been on the genetics of neuropsychiatric conditions related to stress response, depression and addiction. Another area of research is on the genetics and epigenetics of development and aging using both animal models and human cohorts. I consider the joint use of human populations and model organisms, particularly isogenic inbred mouse strains, as a key aspect of my work. I am enthusiastic about applying cross-species comparative genetics to bridge the gap between the basic sciences and human epidemiological and clinical studies.

The work I do is inherently multidisciplinary and incorporates the fields of neuroscience, genomics, bioinformatics and human epidemiology. Methods and approaches include classical genetics, systems genetics, and network analyses that utilize high-dimensional genomic, epigenomic, and transcriptomic data. I rely heavily on resources in bioinformatics and computational tools developed for large “–omics” type data.

Representative Publications 

• Hayden KM, Gaussoin SA, Hunter JC, Manson JE, Sachs BC, Shadyab AH, Tindle HA, Mossavar-Rahmani Y, Mozhui K, Snively BM, Rapp SR, Resnick SM. Cognitive resilience among APOE ε4 carriers in the oldest old. Int J Geriatr Psychiatry. 2019 Dec;34(12):1833-1844. doi: 10.1002/gps.5199. Epub 2019 Aug 22. PubMed PMID: 31418472.
• Tang BM, Shojaei M, Teoh S, Meyers A, Ho J, Ball TB, Keynan Y, Pisipati A, Kumar A, Eisen DP, Lai K, Gillett M, Santram R, Geffers R, Schreiber J, Mozhui K, Huang S, Parnell GP, Nalos M, Holubova M, Chew T, Booth D, Kumar A, McLean A, Schughart K. Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection. Nat Commun. 2019 Jul 31;10(1):3422. doi: 10.1038/s41467-019-11249-y. PubMed PMID: 31366921; PubMed Central PMCID: PMC6668409.
• Bartlett AH, Liang JW, Sandoval-Sierra JV, Fowke JH, Simonsick EM, Johnson KC, Mozhui K. Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults. Biomark Res. 2019 May 28;7:10. doi: 10.1186/s40364-019-0161-3. eCollection 2019. PubMed PMID: 31149338; PubMed Central PMCID: PMC6537435.
• Reidy KJ, Hjorten RC, Simpson CL, Rosenberg AZ, Rosenblum SD, Kovesdy CP, Tylavsky FA, Myrie J, Ruiz BL, Haque S, Mozhui K, Nelson GW, David VA, Yang X, Suzuki M, Jacob J, Reznik SE, Kaskel FJ, Kopp JB, Winkler CA, Davis RL. Fetal-Not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry. Am J Hum Genet. 2018 Sep 6;103(3):367-376. doi: 10.1016/j.ajhg.2018.08.002. Epub 2018 Aug 30. PubMed PMID: 30173819; PubMed Central PMCID: PMC6128247.
• Kocak M, Mozhui K. AN APPLICATION OF THE BAYESIAN PERIODICITY TEST TO IDENTIFY DIURNAL RHYTHM GENES IN THE BRAIN. IEEE/ACM Trans Comput Biol Bioinform. 2018 Jul 25. doi: 10.1109/TCBB.2018.2859971. [Epub ahead of print] PubMed PMID: 30047896.
• Gujar H, Liang JW, Wong NC, Mozhui K. Profiling DNA methylation differences between inbred mouse strains on the Illumina Human Infinium MethylationEPIC microarray. PLoS One. 2018 Mar 12;13(3):e0193496. doi: 10.1371/journal.pone.0193496. eCollection 2018. PubMed PMID: 29529061; PubMed Central PMCID: PMC5846735.

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