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Victor V. Chizhikov, PhD

Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center

The University of Tennessee Health Science Center
855 Monroe Ave, Link Building, Ste 515
Memphis, TN 38163
Phone: 901.448.2309
Fax: 901.448.7193
Lab: 528 Johnson Building
Email: Victor V. Chizhikov


  • PhD Institution: NN Blokhin Cancer Research Center, Moscow, Russia
  • Postdoctoral: University of Chicago, Department of Human Genetics, Chicago, IL

Research Interests

Our laboratory has two goals: (1) to identify the molecular mechanisms that regulate the development of the mammalian brain and (2) to define the pathogenic mechanisms that underlie human developmental brain disorders. Specifically, we focus on two dorsal brain regions - the developing cerebellum and the cerebral cortex. The cerebellum is a major center of motor-coordination and is also involved in certain cognitive functions. The cerebral cortex is responsible for higher brain functions such as learning, memory and perception. Developmental abnormalities of the cerebellum and cerebral cortex are relatively frequent in human patients and are associated with autism, intellectual disability and hydrocephalus. In our laboratory we use the following approaches and techniques: analysis of knockout and transgenic mice, genetic fate mapping, in utero electroporation, explants, laser capture microdissection, in situ hybridization RNA-seq, and immunohistochemistry.

Representative Publications

  • Chizhikov VV, Iskusnykh IY, Steshina EY, Fattakhov N, Lindgren AG, Shetty AS, Roy A, Tole S, Millen KJ. Early dorsomedial tissue interactions regulate gyrification of distal neocortex. Nat Commun. 2019 Nov 15;10(1):5192. doi: 10.1038/s41467-019-12913-z. PubMed PMID: 31729356; PubMed Central PMCID: PMC6858446.
  • Kridsada K, Niu J, Haldipur P, Wang Z, Ding L, Li JJ, Lindgren AG, Herrera E, Thomas GM, Chizhikov VV, Millen KJ, Luo W. Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons. Cell Rep. 2018 Jun 5;23(10):2928-2941. doi: 10.1016/j.celrep.2018.05.025. PubMed PMID: 29874580; PubMed Central PMCID: PMC6174691.
  • Buddington RK, Chizhikov VV, Iskusnykh IY, Sable HJ, Sable JJ, Holloway ZR, Blumenfeld Katzir T, van der Merwe M, Yakimkova T, Buddington KK, Lifshitz Y, Tessler S, Gilbert A. A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs. Nutrients. 2018 May 18;10(5). pii: E637. doi: 10.3390/nu10050637. PubMed PMID: 29783637; PubMed Central PMCID: PMC5986516.
  • Iskusnykh IY, Buddington RK, Chizhikov VV. Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia. Exp Neurol. 2018 Aug;306:209-221. doi: 10.1016/j.expneurol.2018.05.015. Epub 2018 May 14. PubMed PMID: 29772246; PubMed Central PMCID: PMC6291230.
  • Glover JC, Elliott KL, Erives A, Chizhikov VV, Fritzsch B. Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution. Dev Biol. 2018 Dec 1;444 Suppl 1:S14-S24. doi: 10.1016/j.ydbio.2018.02.001. Epub 2018 Feb 12. Review. PubMed PMID: 29447907; PubMed Central PMCID: PMC6087689.
  • Iskusnykh IY, Steshina EY, Chizhikov VV. Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710. doi: 10.1523/JNEUROSCI.2526-15.2016. PubMed PMID: 26937009; PubMed Central PMCID: PMC4879213.

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Apr 23, 2024