Translational Sciences Shared Resource

The Translational Sciences Shared Resource (TSSR) at the UTHSC Center for Cancer Research offers a wide range of services specifically designed to support cancer and cancer-associated research projects, with a primary emphasis on genomics, transcriptomics, metabolomics, microbiome analysis, etc. Our goal is to expedite and enrich cancer-related research, which will ultimately lead to better understanding, diagnosis, and treatment options for cancer patients.

Our team is dedicated to assisting researchers at every stage of their projects, from designing studies to optimizing sample collection and processing, quality control measures, and all the way through to data analysis. We have developed partnerships with vendors to ensure that we can access high-quality services and cutting-edge technologies for our research projects, all while keeping costs reasonable. 

We assist with planning for the following services: 

• DNA and RNA isolation
• DNA library preparation (Hybrid Capture, AmpliSeq)
• Whole genome sequencing (WGS) 
• Whole exome sequencing (WES)
• ATAC sequencing
• RNA sequencing (standard RNA-seq, small RNA-seq, Iso-Seq) 
• Targeted sequencing (For example, cancer-associated gene panel is available upon request)
• Shotgun Metagenomics 
• etc. 

Additionally, we assist in the development of novel platforms (metabolomics, single-cell sequencing, etc.). 

To keep track of our samples and manage the complex processes involved, we utilize the LabVantage laboratory inventory management system (LIMS). This system helps us monitor each sample closely, starting from the moment it arrives until it's processed and analyzed. We work closely with the UTHSC Center for Cancer Research Biorepository Shared Resource to ensure smooth collaboration and efficient management of samples throughout their journey.

Furthermore, informatics support is available through the UTHSC Center for Cancer Research Computational Sciences Shared Resource.