Emerging Stem Cell Technologies and Applications for Tissue Regeneration

The evolution of stem cell transplantation techniques and the discovery of genome-editing methodologies represent significant breakthroughs in life-science research of the 21st century. Furthermore, the technique of 3D bio-printing using stem cells provides additional applications for these technologies in tissue regeneration. This technique has been successful in regenerative medicine for stem cell-derived bio-printed tissues. This area of research aims to develop improved, clinically applicable 3-d bioprinting technologies involving stem cells, gene editing technologies, and targeted delivery of small molecules to manipulate non-malignant and malignant stem cells. Currently, researchers are developing and validating new technologies, in preclinical models, for (1) the targeted delivery of the gene editing molecular machinery and (2) small molecules into different types of stem cells using unique nanotechnology platform(s). stem cell-targeted delivery of molecular cargo will likely significantly impact translational research toward novel clinical therapies for hematopoietic diseases, malignancies, and beyond.