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Congratulations to Dr. Ugochi Ogu on his recent publication!

Congrats to Dr. Ugochi Ogu on being a co-author for 2 chapters in the textbook, “Sickle Cell Disease in Sub-Saharan Africa - Biomedical Perspectives”! The book was published on April 30, 2024. The Chapters are listed below:

Presentation by Center Director Dr. Kenneth I. Ataga

Using Disease Modifying Therapies in Sickle Cell Disease" at an educational session at the 65th annual meeting of the American Society of Hematology in San Diego, CA on December 11, 2023.

Dr. Kenneth

dr. kenneth atega

Congratulations Dr. Ataga on your nomination!

The Memphis Business Journal hosted their 2023 Health Care Heroes Awards on Thursday, August 17, 2023. This event recognized and honored organizations, institutions, and individuals throughout the city of Memphis who have made great contributions in the healthcare field. Dr. Kenneth Ataga was a finalist for the Health Care Innovations award. 

Congratulations Dr. Ataga on your nomination!

Congratulations to Dr. Keesha Roach!

Congratulations to Dr. Keesha Roach, an early career Nurse Scientist at the University of Tennessee Health Science Center. Her daughter recently got married and completed her PhD in Animal Science at Iowa State last month. Way to go!

Ramyla Dahmer, a high school senior living with sickle cell, was presented with the 2023 Dr. Patricia Adams-Graves scholarship.

Ramyla Dahmer, a high school senior living with sickle cell, was presented with the 2023 Dr. Patricia Adams-Graves scholarship.

Ramyla Dahmer holding a large check being presented with 2023 Dr. Patricia Adams-Graves scholarship.

Group photo of every present at the celebration.
Congratulations to The Sickle Cell Foundation of Tennessee on its donation from Tegna Foundation!
A group of people holding a sign
The Sickle Cell Foundation of Tennessee received a $10,000 donation from Tegna Foundation to sponsor a children’s camp for 2023.
Congratulations to Dr. Jane Hankins on a recent grant!
Congratulations to Dr. Jane Hankins, an associate member in the Department of Hematology at St. Jude Children’s Research Hospital for receiving the SCDIC-II registry grant from NHLBI in the amount of $182,799 and the ASH Bridge Grant for mESH2-Optimization of Integration of mHealth into SCD Care to Increase HU Utilization from the American Society of Hematology in the amount of $150,001.
Congratulations to Dr. Rima Zahr on her recent publication!

Patients with sickle cell disease who develop end-stage kidney disease continue to experience poor survival - A 19-year United States Renal Data System study.

Winer JC, Yee ME, Ataga KI, Lebensburger JD, Zahr RS. Br J Haematol. 2022 Oct 3. doi: 10.1111/bjh.18494. Online ahead of print. PMID: 36191963 No abstract available.

Congratulations to Dr. Patricia Adams-Graves for being awarded St. Jude's Spirit of the Dream award!
Dr. Patricia Adams

Congratulations to Dr. Patricia Adams-Graves, a professor in the Hematology/Oncology Division at the University of Tennessee Health Science Center. She was presented with the Spirit of the Dream award by St. Jude on September 29, 2022 for the impact she has made serving and caring for those living with Sickle Cell Disease in the greater Midsouth region.

Foundation for Sickle Cell Disease Research hosts Symposium on Machine Learning
Dr. Ataga

Dr. Ataga is the Scientific Chair for the Foundation for Sickle Cell Disease Research’s September Symposium on Machine Learning, which will occur virtually on September 22, 2022 from 10 am – 4 pm EST. Register for the Symposium.

Sickle Cell Research Event Flyer

Dr. Ugochi Ogu talks with Action News 5 about Sickle Cell Disease.
Recently, Dr. Ugochi Ogu, Assistant Professor of Medicine at the University of Tennessee Health Science Center and Medical Director of the Diggs-Kraus Comprehensive Sickle Cell Center at Regional One, sat down with Action News 5 to answer questions regarding Sickle Cell Disease.
Hematology Speaker Series: New Approaches for Transfusion Support of Sickle Cell Disease on October 19!
Stella Chou

Hematology Speaker Series: New Approaches for Transfusion Support of Sickle Cell Disease

Save the Date!
October 19, 2022
12:00 pm – 1:00 pm

Join us via Zoom:
Meeting ID: 985 3966 3746
Passcode: 965370

Stella Chou, MD
Chief, Division of Transfusion Medicine, The Children's Hospital of Philadelphia Associate Professor of Pediatrics, the Children's Hospital of Philadelphia University of Pennsylvania School of Medicine


1 CME/CEU credit provided

AMA Credit Designation: The University of Tennessee College of Medicine (UTCOM) designates this live activity for a maxium of 1 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Education for Non-Physicians: The UTCOM will issue Certificates of Participation to non-physicians for participating in this activity and designates it for CEUs using the national standard that 1 hour of educational instruction is awarded 1 CEU.

Accreditation: The UTCOM is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.


Sponsored by the Methodist Foundation


Congratulations to Dr. Jane Hankins on her recent publication!
Jane Hankins

Congratulations to Dr. Jane Hankins on her recent publication!

Longitudinal study of glomerular hyperfiltration in adults with sickle cell anemia: a multicenter pooled analysis.  Ataga KI, Zhou Q, Saraf SL, Hankins JS, Ciccone EJ, Loehr LR, Ashley-Koch AE, Garrett ME, Cai J, Telen MJ, Derebail VK; Blood Adv. 2022 August 9.

Congratulations to Dr. Athena Davenport on being awarded tenure as an Associate Professor
Congratulations to Dr. Athena Davenport on being awarded tenure as an Associate Professor and receiving an NIH Loan Repayment renewal Award in Pediatric Research to continue her research project on SCD entitled "MicroRNA-based epigenetic approach to induce fetal hemoglobin".
Congratulations to Dr. Patricia Adams-Graves for the honors she has received in 2022
Dr. Adams-Graves

Congratulations to Dr. Patricia Adams-Graves for being selected to receive the 2022 St. Jude Spirit of the Dream Award presented by ALSAC. This award recognizes the achievements of an African-American who embodies the lifesaving mission of St. Jude Children’s research Hospital and its founder, Danny Thomas.

We also congratulate her for an honor received earlier this year with a scholarship in her name. The Dr. Patricia Adams-Graves Sickle Cell Scholarship was created in collaboration with the Sickle Cell Foundation of Tennessee (SCFTN) and The Memphis Alumnae Chapter of Delta Sigma Theta Sorority, Inc. This scholarship provides financial support toward the pursuit of higher education for high school seniors who have achieved academic excellence while living with sickle cell disease. 

Dr. Adams-Graves is deserving of these honors due to her years of trail-blazing advocacy for those living with sickle cell disease. Her work to implement the first sickle cell disease-specific hospital unit in the nation and a computer education curriculum for nurses who deliver care for sickle cell utilized across the nation have positively impacted the lives of countless individuals with this disease, their families, and their caregivers.

Ataga Leading $3 Million AI Study For Predicting Kidney Function Decline in Sickle Cell Patients

Kenneth Ataga, MD, Director of the Center for Sickle Cell Disease at the University of Tennessee Health Science Center (UTHSC), was recently awarded $3.2 million from the National Heart, Lung and Blood Institute for a project that enlists artificial intelligence in the fight against sickle cell disease. Santosh Saraf, MD, associate professor in the Department of Medicine at the University of Illinois at Chicago, is a co-PI on the grant. (Read More)

Haemoglobin response to senicapoc in patients with sickle cell disease: a re-analysis of the Phase III trial

A recent paper from our group on machine learning and prediction of rapid kidney function decline in sickle cell anemia. (Read the latest publication)

Message from the Chairman of Medicine, G. Nicholas Verne, MD

One of the missions of the Department of Medicine is to foster and develop research.  In efforts to support research and the development of new extramural funding, the DOM has offered 2 Development Grants for this upcoming academic year for faculty in the Department of Medicine.   It is anticipated that this award will culminate in a new grant application by the end of the academic year.  We received many excellent applications for these awards that were peer reviewed by a committee.  I am pleased to announce that the following faculty were selected for funding this year:

Laila Elsherif, PhD
Assistant Professor of Medicine
Division of Hematology & Oncology
“Effect of PAI-1 Increase on Neutrophil Apoptosis Delay in Sickle Cell Disease”

Zhousheng Xiao, PhD
Associate Professor of Medicine
Division of Nephrology
“Novel Role of PC1/PC2 Complex in Adipocyte Metabolism”

Please help me in congratulating our Department of Medicine grant awardees!


NIH Award for Sickle Cell Study Marks Milestone Support For Junior UTHSC Investigator, CORNET Program

This article was originally published on UTHSC News. You can view the original news article here.

Written by Lee Ferguson | August 4, 2020

A new research project that could impact and expand the discovery of new treatment options for sickle cell patients has received significant federal funding. The National Heart, Lung, and Blood Institute awarded nearly $1 million to Athena Starlard-Davenport, PhD, assistant professor of Genetics, Genomics, and Informatics in the UTHSC College of Medicine, for her project titled, “MicroRNA-based epigenetic approach to induce fetal hemoglobin.”

The grant, the first national award for Dr. Starlard-Davenport, is also a significant milestone for UTHSC’s Office of Research, as it puts the total external dollars generated from CORNET-funded work over the $20 million mark. The CORNET Awards are a seed funding program for interdisciplinary collaborations on new research.

“For the past 100 years, only four drugs have been approved by the FDA for the treatment of sickle cell disease,” Dr. Starlard-Davenport said. “Those patients need more treatment options depending on their symptoms and complications.”

Sickle cell disease is very common. One in 13 African Americans have the sickle cell trait and over 100,000 people in the U.S. have sickle cell disease. Individuals with sickle cell suffer from severe pain crises that increase their risk of organ failure and premature death. The sickle cell mutation causes production of abnormal sickle hemoglobin during the first year of life, when the body makes its switch from producing fetal hemoglobin (gamma globin) to adult beta globin. Fetal hemoglobin is normal in people with sickle cell disease; it is only the adult form of sickle hemoglobin that is abnormal. Scientists have found that reversing this normal switch, i.e. turning the gamma globin gene back on, counteracts symptoms, improves health outcomes and prolongs the lifespan of sickle cell patients.

To date, hydroxyurea is  the only FDA-approved drug with proven efficacy to do that. Though another class of epigenetic modulators − DNA methyltransferase (DNMT) inhibitors – has shown promise inducing fetal hemoglobin in sickle cell patients, they produce off-target side effects. Dr. Starlard-Davenport’s research is focused on a specific small molecule in this class, miRNA29b, for further study.

Dr. Starlard-Davenport has been investigating miRNA29b and fetal hemoglobin induction for four years. She got her start in 2016 with help from a new seed funding initiative launched that year by the UTHSC Office of Research, the CORNET Awards. She and her collaborator, Patricia Adams-Graves, PhD, professor of Medicine and hematologist at the Diggs-Kraus Sickle Cell Clinic at Regional One Health, won a CORNET in the Clinical Awards division for their project, “Investigation of miR29 as a novel fetal hemoglobin inducer and treatment for patients with sickle cell disease.”

“The CORNET award provided funding support to collect blood samples from sickle cell patients and to test whether our miRNA therapeutic could increase levels of fetal hemoglobin in vitro in cell culture and in preclinical sickle cell models. We did this work in collaboration with Betty Pace at Augusta University,” Dr. Starlard-Davenport said. Betty Pace, MD, is the Tedesco Distinguished Chair of Pediatric Hematology/Oncology at Augusta University. “The funding was used to purchase reagents for running the necessary biochemical assays, including our miRNA mimic, cell culture reagents.”

The CORNET program was begun by Steven Goodman, PhD, vice chancellor for Research, to encourage interdisciplinary collaboration on new research that will lead to larger, national grants. In the nearly four years since their inception, the awards have supported 52 new collaborative research teams and their groundbreaking initiatives. With this latest national award, external dollars generated from CORNET work has reached $20,604,972, an 11.6-fold return on a $1.78 million investment.

“This NIH award for studies to increase fetal hemoglobin expression thereby reducing sickle cell severity is important for many overlapping reasons,” Dr. Goodman said. “It is the first NIH award for Dr. Starlard-Davenport. We were able to assist Athena and her colleagues to obtain the preliminary data that led to the award through the CORNET award program. This extramural award put the CORNET program over the $20 million threshold in return on investment. Dr. Starlard-Davenport has been a mentee in the wonderful PRIDE program, which focuses on jump-starting the career of junior underrepresented minority faculty. The director of this PRIDE Program is Dr. Betty Pace who mentored Dr. Starlard-Davenport and is an investigator on the NIH Award. It is amazing how many stars aligned in this one NIH award to a very deserving new investigator. But most important is the impact that this study can have upon the quality of life of people around the globe who suffer from this genetic disease.”

“In the initial CORNET application, my team provided preliminary results to show that miRNA29b could increase levels of fetal hemoglobin in a compatible human cell line, but we needed further preliminary data to determine what effect miRNA29b had on fetal hemoglobin induction in red blood cells from individuals with and without sickle cell disease,” Dr. Starlard-Davenport said. The NIH funding she just received, $928,317 to be distributed over three years, will allow her team to collect blood samples from sickle cell patients and test whether this molecule increases the expression of fetal hemoglobin that blocks sickle hemoglobin polymerization and improves clinical symptoms. The long-term goal is to develop miRNA29b as a new drug for treating patients with sickle cell.

Dr. Starlard-Davenport is the principal investigator on a team of clinicians and scientists that includes, in addition to Dr. Adams-Graves and Dr. Pace, Ken Ataga, MD, director of the UTHSC Center for Sickle Cell Disease; Daniel Johnson, PhD, director of the UTHSC Molecular Bioinformatics Center; and Biaouri Li, MD, professor in the department of Pediatric Hematology/Oncology at Augusta University.

UTHSC Hosts Impressive Roster of Sickle Cell Researchers at 2019 Norfleet Forum

This article was originally published on UTHSC News. You can view the original news article here.

View a video recording of the 2019 Norfleet Forum at the following links. Part 1 | Part 2

forum photos forum photo forum photo forum photo forum photo

Clinicians and researchers from around the country gathered in Memphis Friday for the 2019 Frank M. Norfleet Forum for the Advancement of Health to discuss sickle cell disease research and treatment. They looked back at how the disease has developed over the last century and what the future holds for those born with it and those who are trying to cure it.

Themed “More than 100 years of Sickle Cell Disease: Development of Novel Therapies,” the daylong conference at the National Civil Rights Museum was organized and led by Kenneth Ataga, MD, director of the Center for Sickle Cell Disease at the University of Tennessee Health Science Center and the Memphis Consortium for Sickle Cell Disease and Non-Malignant Hematology Research. Dr. Ataga joined UTHSC in 2018 and is recognized nationally and internationally as an expert clinician and researcher in the field of sickle cell disease.

Progress has been made in diagnosing and treating sickle cell disease, the panelists said.

Improvements in drug therapies, screening for the disease at birth, better supportive care, developing gene therapy, and ongoing research have improved outcomes for those with the disease.

“A lot of work still has to be done,” Dr. Ataga told the group.

He said it is necessary to improve access to comprehensive care by specialists, increase advocacy for those with the disease, improve the infrastructure for clinical trials, and promote drug discovery and testing of novel compounds to treat the disease.

Health disparities, including poverty and lack of access, prevent many patients around the world from getting the care that could improve their quality of life.

Panelists included researchers from Boston Children’s Hospital, Albert Einstein College of Medicine, Duke Comprehensive Sickle Cell Center, St. Jude Children’s Research Hospital, Cincinnati Children’s Hospital, and Vanderbilt University.

The first Norfleet Forum was held in 1980 at UTHSC. The annual conference was created to focus on the improvement of health in the community, the state, and around the world through discussion of health policies and developments. It was funded by a gift to the university in honor of Memphis businessman Frank M. Norfleet through the Community Foundation of Greater Memphis. Other recent topics have included kidney disease in the African American community, childhood obesity, and alcohol use disorders.

Jon McCullers, MD, chair of pediatrics at UTHSC and pediatrician in chief at Le Bonheur Children’s Hospital, said the Norfleet Forum allows the university to improve scientific and community knowledge on relevant health care issues and to foster collaboration among researchers that could result in moving science forward.

“Norfleet allows us to bring in 10 or 15 outside speakers, which is a tremendous thing that you don’t see at a local or regional conference,” he said. “It’s unique and it’s very much appreciated. “

Dean Strome announces award of internal funds

The University of Tennessee Health Science Center College of Medicine's Executive Dean Scott Strome announced the award of internal funds to four projects in the College of Medicine at Memphis. 

For the Collaborative Intramural Research in the College of Medicine (CIRCA) support program the following were selected for funding:

The Association of Podocyturia with Progressive Glomerular Injury in Sickle Cell Disease

o   Kenneth I. Ataga, MD, Plough Foundation Endowed Chair & Professor of Medicine and Pediatrics

o   Adebowale Adebiyi, PhD, Associate Professor, Department of Physiology 

The goal of the CIRCA program is to stimulate innovative, interdisciplinary, team research leading to submission of an R01-scale grant application.  Specifically, CIRCA is designed to fund innovative research collaborations between a clinician (patient care responsibilities and/or a clinical researcher) and basic researcher in different departments. Matthew Ennis, PhD, Chair of the CIRCA proposal review committee noted “There were many meritorious applications and the decision to fund 2 proposals was an excellent choice based on thorough review by a committee with broad research expertise."

Kenneth Ataga, MD, co-authors paper on potential new treatment for sickle cell disease

This article was originally published on UTHSC News. You can view the original news article here.

Written by Sarah Ashley Bloch | June 26, 2019

Newly published results from a multinational study co-authored by Kenneth Ataga, MD, director of the Center for Sickle Cell Disease at the University of Tennessee Health Science Center (UTHSC) and the Memphis Consortium for Sickle Cell Disease and Non-Malignant Hematology Research, indicated voxelotor, a novel experimental drug for sickle cell disease, reduced anemia and boosted the health of red blood cells in patients. Dr. Ataga is also the Methodist Endowed Chair in Sickle Cell Anemia at Methodist Le Bonheur Healthcare.

Sickle cell disease is an inherited blood disorder that affects red blood cells. It is caused by a genetic mutation in hemoglobin, resulting in the formation of abnormal hemoglobin known as sickle hemoglobin (HbS). Deoxygenation and the sickling of red blood cells can lead to chronic anemia and hemolysis, and ultimately result in multiorgan damage, stroke, and premature death. More than 100,000 Americans are affected by sickle cell disease, and Memphis has one of the largest populations for adult sickle cell disease in the country. There are only two U.S. Food and Drug Administration-approved treatment options currently available.

“With the limited drug therapies available for patients with sickle cell disease, the findings of this trial are quite exciting,” said Dr. Ataga, who also serves as the Plough Foundation Endowed Chair in Sickle Cell Disease. “With the complex nature of sickle cell disease, the development of drugs that have different mechanisms of action offers an opportunity for combination drug therapy and for individualized therapy based on the presence of specific disease-related complications.”

The Biopharmaceutical company Global Blood Therapeutics, Inc. aims to bring voxelotor to the market as a third treatment option.

Designed to evaluate the efficacy and safety of voxelotor, the phase 3 Hemoglobin Oxygen Affinity Modulation to Inhibit HbS PolymErization (HOPE) Study enrolled 274 patients, ages 12 to 65, with sickle cell disease, from 60 institutions across 12 countries. The patients were divided into three trial groups that received either a 900-mg or 1,500-mg daily dose of voxelotor or a placebo. Clinical assessments were performed at various time points throughout the trial.

The study found that 51 percent of the participants who were administered the higher dose of voxelotor experienced a significant increase in hemoglobin levels after six months of treatment compared to seven percent in the placebo group. In addition, voxelotor treatment reduced the incidence of worsening anemia and the amount of hemolysis. Voxelotor was also deemed safe and well-tolerated by participants.

“While voxelotor improved anemia in the study patients, more studies are required to show whether there are also improvements in other sickle cell disease-related complications,” Dr. Ataga said.

Longer-term follow-up studies are being planned to assess voxelotor’s effects on vaso-occlusive crisis (or sickle cell crisis), morbidity, and mortality in sickle cell patients.

The HOPE Study results were recently published in The New England Journal of Medicine and presented at the European Hematology Association 24th Congress in Amsterdam.

Jun 14, 2024