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Stanislav S. Zakharenko, MD, PhD

Department of Developmental Neurobiology
St. Jude Children's Research Hospital

Affiliate Professor
Department of Anatomy and Neurobiology

St. Jude Children's Research Hospital
262 Danny Thomas Place, MS 324
Memphis, TN 38105-3678
Tel: 901.595.3837
Fax: 901.595.3143
Lab: MS 324, Room D2025B
Email: Stanislav S. Zakharenko


Research Interests

  • Functional organization and synaptic plasticity in the auditory cortex
  • Molecular and cellular mechanisms of cognitive deficits during schizophrenia
  • Synaptic plasticity in the hippocampus

Representative Publications

  • Davenport CM, Teubner BJW, Han SB, Chang T-C, Garic D, Patton MH, Eom T-Y, Lansdell BJ, Shirinifard A, Klein J, Pruett-Miller SM, Blundon JA, Zakharenko SS. Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice. Cell 185(21): 3877-3895, 2022. Highlighted in NatureEurekAlert and others.

  • Eom T-Y, Han SB, Kim J, Blundon J, Wang Y-D, Yu J, Anderson K, Kaminski DB, Sakurada SM, Pruett-Miller SM, Horner L, Wagner B, Robinson CG, Eicholtz M, Rose D, Zakharenko SS. Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice. Nature Communications 11(1):912, 2020. doi: 10.1038/s41467-020-14628-y. Highlighted in Science Daily, EurekAlerts, MedicalXpress.

  • Patton MH, Blundon JA, Zakharenko SS. Rejuvenation of plasticity in the brain: opening the critical period. Current Opinion in Neurobiology 54:83-89, 2019.

  • Blundon JA, Roy NC, Teubner BJ, Yu J, Eom T-Y, Sample KJ, Pani A, Smeyne RJ, Han SB, Kerekes RA, Rose DC, Hackett TA, Vuppala PK, Freeman 3rd BB, Zakharenko SS. Restoring auditory cortical plasticity in adult mice by restricting thalamic adenosine signaling. Science 356(6345):1352-1356, 2017. Highlighted in Science 356(6345):1335-1336Science DailyScientific AmericanDaily MailWall Street Journal, and others.

  • Chun S, Du F, Westmoreland JJ, Han SB, Wang Y-D, Eddins D, Bayazitov IT, Devaraju P, Yu J, Mellado Lagarde MM, Anderson K, Zakharenko SS. Thalamic miR-338-3p mediates thalamocortical disruption and its late onset in 22q11 deletion syndrome models. Nature Medicine, (23)1:39-48, 2017. Highlighted in Nature Reviews Neuroscience, Forbes MagazineSchizophrenia Research Forum, and others.

  • Eom T-Y, Bayazitov IT, Anderson K, Yu J, Zakharenko SS. Schizophrenia-related microdeletion impairs emotional memory through microRNA-dependent disruption of thalamic Inputs to the amygdala. Cell Reports 19(8):1532-1544, 2017.

  • Devaraju P, Yu J, Eddins D, Mellado Lagarde MM, Earls LR, Westmoreland JJ, Quarato G, Green DR, Zakharenko SS. Haploinsufficiency of the 22q11.2-microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through deregulation of mitochondrial calcium. Molecular Psychiatry 22:1313-1326, 2016. doi:10.1038/mp.2016.75.

  • Chun S, Westmoreland JJ, Bayazitov IT, Eddins D, Pani AK, Smeyne RJ, Yu J, Blundon JA, Zakharenko SS. Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models. Science 344(6188):1178-82, 2014. *Selected by the Faculty of 1000.

  • Earls L.R., Zakharenko S.S. A synaptic function approach to investigating complex psychiatric diseases. The Neuroscientist, 20(3):257-2712013.

  • Blundon JA, Zakharenko SS. Presynaptic gating of postsynaptic plasticity: a plasticity filter in the adult auditory cortex. The Neuroscientist 19(5):465-78, 2013.

  • Earls LR, Fricke RG, Yu J, Berry RB, Baldwin L, Zakharenko SS. Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia. Journal of Neuroscience 32(41):14132-14144, 2012. *Selected by the Faculty of 1000.

  • Earls LR, Bayazitov IT, Fricke RG, Berry RB, Illingworth E, Mittleman G, Zakharenko SS. Dysregulation of presynaptic calcium, synaptic plasticity and spatial memory in a mouse model of 22q11 deletion syndrome. Journal of Neuroscience 30(47):15843-15855, 2010. *Selected by the Faculty of 1000.

  • Richardson RJ, Blundon JA, Bayazitov IT, Zakharenko SS. Connectivity patterns revealed by mapping of active inputs on dendrites of thalamorecipient neurons in the auditory cortex. Journal of Neuroscience 29(20):6406-6417, 2009. *Selected by the Faculty of 1000.

  • Blundon JA, Zakharenko SS. Dissecting the components of long-term potentiation. The Neuroscientist 14(6):598-608, 2008.

View more references (pubmed link)

Jul 19, 2023