Nawajes Mandal, PhD

Dr. Nawajes Mandal

Associate Professor
Department of Ophthalmology
Department of Anatomy and Neurobiology

Hamilton Eye Institute
University of Tennessee Health Science Center
930 Madison Ave, Ste 718
Memphis, TN 38163
Tel: (901) 448-7740
Fax: (901) 448-5028
Email: Nawajes Mandal

Education

  • PhD Institution: Indian Agricultural Research Institute, Division of Biochemistry, New Delhi, India
  • Postdoctoral: University of Michigan, Department of Ophthalmology

Research Interests

Sphingolipid (lipid) metabolism and signaling in the retina and other ocular diseases; Sphingolipids in human diabetes, inflammation and autoimmune diseases; Development of therapeutics targeting sphingolipid pathways for eye diseases.

We discovered many roles of sphingolipids in the eye including the specific balance of sphingolipid metabolite ceramide and sphingosine 1-phosphate (S1P) required for proper functioning of the retinal photoreceptors. We also determined that S1P participates in the cellular junctional complexes and barrier formation in photoreceptor and RPE cells. S1P plays a role in vascular maturation and our research has provided important insights into its role in ocular vascular diseases such as wet-AMD, retinopathy of pre-maturity (ROP), and corneal neovascularization. S1P is also involved in tissue fibrosis; another area of our research focus is, understanding the role of S1P and its signaling in corneal wound healing and fibrosis.

Representative Publications

  • Wilkerson JL, Stiles MA, Gurley JM, Grambergs RC, Gu X, Elliott MH, Proia RL, Mandal NA. Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. Mol Neurobiol. 2019 Apr 17. doi: 10.1007/s12035-019-1599-x. [Epub ahead of print] PubMed PMID: 30997640.
  • Wilmott LA, Grambergs RC, Allegood JC, Lyons TJ, Mandal N. Analysis of sphingolipid composition in human vitreous from control and diabetic individuals. J Diabetes Complications. 2019 Mar;33(3):195-201. doi: 10.1016/j.jdiacomp.2018.12.005. Epub 2018 Dec 14. PubMed PMID: 30630661; PubMed Central PMCID: PMC6368445.
  • Porter H, Qi H, Prabhu N, Grambergs R, McRae J, Hopiavuori B, Mandal N. Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina. Int J Mol Sci. 2018 Dec 5;19(12). pii: E3885. doi: 10.3390/ijms19123885. PubMed PMID: 30563056; PubMed Central PMCID: PMC6321283.
  • Paranjpe V, Tan J, Nguyen J, Lee J, Allegood J, Galor A, Mandal N. Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition. Ocul Surf. 2018 Dec 12. pii: S1542-0124(18)30196-4. doi: 10.1016/j.jtos.2018.12.006. [Epub ahead of print] PubMed PMID: 30553001.
  • Sugano E, Edwards G, Saha S, Wilmott LA, Grambergs RC, Mondal K, Qi H, Stiles M, Tomita H, Mandal N. Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress. J Lipid Res. 2019 Jan;60(1):30-43. doi: 10.1194/jlr.M082198. Epub 2018 Nov 9. PubMed PMID: 30413652; PubMed Central PMCID: PMC6314257.
  • Nicholas SE, Rowsey TG, Priyadarsini S, Mandal NA, Karamichos D. Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. PLoS One. 2017 Aug 14;12(8):e0182390. doi: 10.1371/journal.pone.0182390. eCollection 2017. PubMed PMID: 28806736; PubMed Central PMCID: PMC5555661.

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