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Medicinal Chemistry Core

The Medicinal Chemistry (MedChem) Core was established through the Office of the Vice Chancellor for Research in September of 2017. This new institutional core will assist UTHSC investigators in all aspects of small molecule drug development and research, including, but not limited to, target validation, lead optimization, tool compound custom synthesis, small scale and multi-gram scale synthesis and purification, structural determination, and purity analysis.

CEM Discover SP Microwave

Reveleris® PREP Purification System

Facilities

The core located in the College of Pharmacy Building with 400 sq ft of synthetic chemistry laboratory. This laboratory space is equipped with 33 sq ft of fume hoods, balances, heating mantles, stirrers, refrigerators, freezers, Buchi R-300 rotary evaporators with V-300 vacuum pumps, a lab oven, a Labconco Freezone 4.5 Liter lyophilizer, a Buchi Melting Point M-565, and a Reveleris PREP Purification System.

Services

  • Target Validation and Drug Design
  • Lead Optimization
  • Small Molecule Custom Synthesis
  • Scale-Up Synthesis and Purification
  • Structural Determination by NMR, MS, Elemental Analysis, et al
  • Consultation on any Issue about Chemistry and Chemicals

Core Director

Dr. Jiawang Liu, the core director, joined the UTHSC in September of 2017. He earned his BS in Pharmaceutical Science (2002) and his PhD in Medicinal Chemistry (2007) from Peking University Health Science Center, College of Pharmaceutical Science, Beijing, China. He has over 15 years of experience in drug design, synthesis, and screening, with 45 scientific papers published in the peer-reviewed journals.

May 26, 2022