Jonathan H. Jaggar, Ph.D.

Jaggar photo

Bronstein Endowed Professor of Physiology
847 Monroe Ave
Johnson Building
Memphis, TN 38163

Phone: 901-448-1208
Fax: 901-448-7126


Coventry University, Coventry, UK, B.S. Applied Biology, 
University of Sheffield, Sheffield, UK, 1991-1995, Ph.D., Potassium Channels
University of Vermont, Burlington, VT, 1995-1999, Postdoc., Vascular Physiology

Research Interest

My research program investigates the regulation of arterial contractility and systemic blood pressure by ion channels that are expressed in arterial smooth muscle and endothelial cells. My laboratory also examines pathological alterations that occur in ion channels that lead to cardiovascular diseases, including hypertension and stroke. Ion channels that we currently study include TRP, KV, ANO1 and CaV1.2.  We use a broad range of techniques that incorporates the use of a molecular, biochemical, cellular, and functional approaches, making the research translational. Methods used in the laboratory include developing novel cell-specific gene knockout and cardiovascular disease models, RT-PCR, Western blotting, biotinylation, FRET, RNAi, co-IP, immunofluorescence, patch-clamp electrophysiology, membrane potential recording, intracellular Ca2+ imaging, arterial myography and blood pressure telemetry.

Representative Publications

  1. Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH.  Dynamic Regulation of β1 subunit Trafficking Controls Vascular Contractility.  Proc Natl Acad Sci USA 2014; 111(6):2361-2366.  PMID: 24464482
  2. Evanson, KW, Bannister JP, Leo MD, Jaggar JH.  LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.  Circ Res 2014; 115(4):423-341.  PMID: 24906643
  3. Kidd MW, Leo MD, Bannister JP, Jaggar JH.  Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells. Science Signaling 2015; 8(390):ra83. doi: 10.1126/scisignal.aac5128. PMID: 26286025
  4. Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA and Jaggar JH. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Science Signaling 2017; 10, eaah5417. PMID: 28487419.
  5. Zhai X, Leo, MD and Jaggar JH. Endothelin-1 stimulates vasoconstriction through Rab11A serine 177 phosphorylation. Circ Res 2017; 121(6):650-661. doi: 10.1161/CIRCRESAHA.117.311102 PMID: 28696251.

Additional Information