Marcia G. Honig, PhD

Marcia G. Honig, Ph.D.

Department of Anatomy and Neurobiology

The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-5998
Fax: (901) 448-7193
Lab: 534 Johnson Building
Email: Marcia G. Honig



  • PhD Institution: Yale University, Department of Biology
  • Postdoctoral: State University of New York at Stony Brook, Department of Neurobiology and Behavior; University of Michigan, Department of Biology

Research Interests

The research in my laboratory is focused on examining the behavioral consequences of traumatic brain injury (TBI) and the associated pathological changes, through the use of a mouse model.  We create the injury by delivering a high-pressure air blast to a restricted part of one side of the cranium, after anesthetizing and stabilizing the mouse to restrict its movement and shielding the rest of the head and the entire body from the blast.  In terms of the biomechanical forces produced by the air blast, the functional deficits exhibited by the mice, and the widespread axonal injury later observed with histological analysis, our model very much mimics the mild TBI (i.e. concussion) sustained by humans during traumatic incidents such as sports injuries, motor vehicle accidents, and falls, where the skull remains intact.  Accompanying the initial axonal injury, microglia become activated and the ensuing neuroinflammation contributes to further pathogenesis.

We are currently pursuing this in two ways.  First, we are utilizing a pharmacological agent that modulates microglia in such a way as to improve the outcome from TBI, and may also provide benefit in neurodegenerative diseases such as Alzheimer’s and ALS where neuroinflammation contributes to disease progression.  Secondly, we are examining how neuroinflammatory responses contribute to long-term decline, particularly with regard to cognitive function and following multiple traumatic events.

Recent Publications