Jonathan H. Jaggar, Ph.D.

Jonathan H. Jaggar, Ph.D.

Maury Bronstein Professor
Department of Physiology


The University of Tennessee Health Science Center
894 Union Avenue
Memphis, TN 38163
Phone: (901) 448-1208
Office: 402 Nash Research Building
Email: Jonathan H. Jaggar


Education

  • Ph.D. Institution: University of Sheffield, United Kingdom

Research Interests

Arterial diameter, a primary determinant of systemic blood pressure, is regulated by the contractile state of smooth muscle cells in the arterial wall. One critical regulator of smooth muscle contractility is the intracellular calcium ion concentration. Smooth muscle cells control intracellular calcium concentration by regulating cellular influx, release, sequestration and extrusion. Since membrane potential regulates calcium entry in smooth muscle cells, ion channels that modulate membrane potential also change cellular contractility. Recent studies have discovered that local and global elevations in cytosolic calcium occur in smooth muscle cells. These different calcium signaling events not only regulate contractility, but may also regulate a number of other physiological functions. We are currently investigating sarcolemma ion channels that control membrane potential and calcium entry in arterial smooth muscle cells and the properties, physiological targets, and regulation of arterial diameter by different intracellullar calcium signals. Research in the laboratory involves a multi-faceted approach, studying events at molecular, cellular and intact artery levels. Techniques include patch clamp electrophysiology, rapid confocal calcium imaging, conventional calcium imaging, diameter measurement of pressurized arteries, and molecular biology.

Representative Publications

  • Leo MD, Zhai X, Yin W, Jaggar JH. Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats. Hypertension. 2018 Jul 16. pii: HYPERTENSIONAHA.118.11147. doi: 10.1161/HYPERTENSIONAHA.118.11147. [Epub ahead of print] PubMed PMID: 30012867.
  • Dopico AM, Bukiya AN, Jaggar JH. Calcium- and voltage-gated BK channels in vascular smooth muscle. Pflugers Arch. 2018 Sep;470(9):1271-1289. doi: 10.1007/s00424-018-2151-y. Epub 2018 May 11. Review. PubMed PMID: 29748711.
  • Pichavaram P, Yin W, Evanson KW, Jaggar JH, Mancarella S. Elevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects. Cardiovasc Res. 2018 Apr 1;114(5):668-678. doi: 10.1093/cvr/cvy015. PubMed PMID: 29360991.
  • Leo MD, Jaggar JH. Trafficking of BK channel subunits controls arterial contractility. Oncotarget. 2017 Nov 3;8(63):106149-106150. doi: 10.18632/oncotarget.22280. eCollection 2017 Dec 5. PubMed PMID: 29290926; PubMed Central PMCID: PMC5739711.
  • Hasan R, Jaggar JH. K(V) channel trafficking and control of vascular tone. Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12418. Review. PubMed PMID: 28963858; PubMed Central PMCID: PMC5760341.
  • Zhai X, Leo MD, Jaggar JH. Endothelin-1 Stimulates Vasoconstriction Through Rab11A Serine 177 Phosphorylation. Circ Res. 2017 Sep 1;121(6):650-661. doi: 10.1161/CIRCRESAHA.117.311102. Epub 2017 Jul 10. PubMed PMID: 28696251; PubMed Central PMCID: PMC5581242.

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