All microCAT systems can be configured with optional high resolution SPECT detector heads for multi-modality studies. With the optional variable focus x-ray source, images down to 15 micron resolution can be acquired in vivo.The Imtek MicroCAT II scanner is an X-ray computed tomography system capable of performing non-invasive imaging studies of tissue specimens or rats or mice in vivo. Sequential scans over time can be done using the same animals thereby reducing the number needed per experiment. The imaging system with a 60 kVp x-ray source and 1024 x 1024-pixel CCD detector provides a 50 mm diameter x 50 mm long cylindrical fi eld of view (mouse), or 100 mm diameter x 50 mm long FOV for rat studies, with 50 micron (10% MTF) reconstructed image resolution. This translates into a six-minute scan of a whole mouse. The source can also be operated at a maximum voltage of 90kVp to provide a 10-micron focal spot. With this option, the scanner can be re-confi gured by the user to provide 6-10- micron resolution (10% MTF) reconstructed images. Gantry includes a four-axis precision motion control system, vibration isolation, a fully interlocked FDA compliant x-ray cabinet, and a removable mouse/specimen bed. The system computer is a dual processor 2 GHz Pentium IV workstation with 1 GB RAM, >100 GB RAID storage and an ultra-high resolution fl at-panel display. Data acquisition, image reconstruction, and Amira TM (Indeed-Software GmbH) Advanced 3D Visualization and Volume Modeling software packages are provided. System operation and scanning of specimens/animals is provided by trained personnel or user and software analyses training can be arranged by appointment. The MicroCAT system configuration includes a dualhead single photon emission tomography (SPECT) data acquisition system so monitoring and distribution of radiolabeled compounds can be superimposed on MicroCT scans. Micro-SPECT will enable three-dimensional cross-sectional imaging of distribution of radiolabel in small laboratory animals or tissue specimens at a spatial resolution in the micron \range. This dual MicroCAT+ SPECT functionality provides high resolution, high sensitivity, in vivo imaging to detect and quantify anatomical and functional changes associated with disease progression, and evaluate therapeutic efficacy.

Key Features

  • Superior image quality due to low-noise CCD detectors
  • Unique capability to adjust x-ray source and detector positions for high resolution and Field of View (FOV)
  • Multiple options for high speed 3-D reconstruction
  • Optional high resolution SPECT detector for integrated SPECT/CT

Representative Studies

  • Skeletal biology and disease: provides accurate calibrated measures of bone mineral density (BMD) and other structural
    parameters, 3-D rendering of trabecular architecture and bone/biomaterial interfaces.
  • Joint degeneration: characterizes anatomical changes in joint space, and density/architectura changes in subchondral bone, measurement of soft tissue edema.
  • Oncology: measures solid tumor volume and quantify metastases; differentiates normal tissues from tumors through analysis of vascularity.
  • Cardiovascular and respiratory disease: characterizes anatomical differences in tissue, organ, such as airway structures, vessel geometry, etc.
  • Functional imaging with integrated microCT/SPECT: provides insight into biologic processes in living animals by imaging the deposition of labeled antibodies or uptake of labeled molecules. The disease progression as well as therapeutic intervention can be studied in a single animal.