Current Research Studies




Aging/Elderly/Medicarearrow Back to top

Health ABC (Health, Aging and Body Composition Study)
(PI - Suzanne Satterfield, M.D., Dr.P.H.)
The Health ABC Study is an observational, clinical research study funded by the National Institute on Aging in 1997. The study was designed to investigate the decline in function in healthier older persons and to relate changes in body composition in old age, particularly the increase in body fat and the decline in lean mass and bone mineral density, to the development of disability. Two clinical centers, UTHSC (Memphis) and the University of Pittsburgh enrolled 3075 participants, aged 70-79, in Health ABC in 1997-98; participants were recruited primarily from a random sample of Medicare-eligible, community-dwelling persons living in the two communities. Eligibility criteria included self-reported ability to walk one-quarter of a mile and climb 10 steps without difficulty, self-reported ability to perform activities of daily living (ADLS) without difficulty, and no life-threatening cancer diagnosis. Follow-up included annual clinic or home visits (Year 1-6, 8, 10, 11, and 16) and semi-annual telephone visits. From Year 15-17 quarterly telephone visits including questions about end-of-life decision making were conducted with participants. Measurements of body composition, bone mineral density, strength, weight, cognitive function, pulmonary function as well as electrocardiography, various laboratory assessments, serum, plasma, DNA, and urine were obtained in clinic visits. Data collection also included questions on diet, depression, medications, ADLS, physical activity, social support, general health, and health events. Data collection and follow-up ended on 9/30/14. Contact Dr. Satterfield for more information or to inquire about potential collaborations and data analysis proposals. For online information, see www.grc.nia.nih.gov/branches/ledb/healthabc.

REACH VA Dementia (Resources for Enhancing All Caregivers Health in the VA)
(PI - Jennifer Martindale-Adams, EdD and Linda O. Nichols, PhD)
REACH VA is an award-winning, evidence-based program to assist stressed and burdened caregivers of Veterans with dementia or spinal cord injury/disease. Based on 16 years of research, REACH VA helps caregivers manage the patient's condition and their own stress from caregiving. REACH VA is a VA system-wide program, training staff at VA Medical Centers around the country, based at the Memphis VA Medical Center. For more information, email vhamemsbm@va.gov, or call (901) 577-7485 or (800) 636-8262, ext. 7485.

ASPREE (ASPirin in Reducing Events in the Elderly)
(PI - Suzanne Satterfield, M.D., Dr. P.H.)
The purpose of ASPREE is to determine whether low dose aspirin will extend the duration of disability-free life in an aging population (greater than 65 years of age). The study examines whether the potential benefits of this drug (prevention of heart disease, stroke and vascular dementia) outweigh the risks of severe bleeding in this age group.

Hospital Responses to Medicare's Nonpayment for Preventable Complications
INACTIVE (PI - Teresa Waters, PhD)
On October 1, 2008, Medicare implemented a new policy that denies incremental payment for eight preventable complications of medical care. Even though this CMS policy is limited in terms of involved conditions, hospital reaction may be substantial because this policy change is viewed by many as the first in a series of CMS payment reforms intended to increase its emphasis on value-based purchasing, using both positive incentives and negative penalties. Our study examines the impact of Medicare's new nonpayment rule on hospital behavior for four of the eight conditions identified by CMS as preventable. We are also assessing how hospital responses may vary depending on particular circumstances, such as hospital financial health and market conditions.

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.

Community Oncology Medical Home (COME HOME)
INACTIVE (PI - Teresa Waters, PhD)
The purpose of this project is to develop a model Community Oncology Medical Home to improve health outcomes, enhance patient care experiences and significantly reduce costs of care. We believe that this is possible by improving timeliness and coordination of care and by keeping patients out of the emergency department (ED) and hospital as much as possible. The target population for this project is newly diagnosed or relapsed Medicare, Medicaid and commercially insured patients seeking oncology care at one of 7 participating clinics. These patients require the wide range of coordinated care that COME HOME can deliver. The services to be delivered include all outpatient cancer care, including: triage pathways that ensure patients receive the right care in the right place at the right time for all aspects of cancer care, diagnostic pathways that address appropriate imaging, pathologic testing and molecular diagnostics, and therapeutic pathways delineating chemotherapy, radiation oncology, supportive care, and surgery (when applicable). The enhanced services offered under the COME HOME program include: patient education and medication management counseling, team care, 24/7 practice access (telephone triage, night/weekend clinic hours, and on-call oncologists), on-site or near-site imaging and laboratory testing, and admitting physicians who shepherd patients through inpatient encounters, avoiding handoffs and readmissions, to ensure seamless, safe and efficient care. Our outcomes analysis will focus on quality of care, outcomes and costs compared to other oncology practices.

Cancerarrow Back to top

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.

Look AHEAD (Action for Health in Diabetes)
(PI - Karen Johnson, MD, MPH)
Look AHEAD is a multicenter, randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. Look AHEAD has over 5,000 persons with type 2 diabetes participating at 16 centers and is funded by the National Institute of Diabetes, Digestive Disorders and Kidney Disease (NIDDK). For more information about the trial go to https://www.lookaheadtrial.org/public/home.cfm.

Health ABC (Health, Aging and Body Composition Study)
(PI - Suzanne Satterfield, M.D., Dr.P.H.)
The Health ABC Study is an observational, clinical research study funded by the National Institute on Aging in 1997. The study was designed to investigate the decline in function in healthier older persons and to relate changes in body composition in old age, particularly the increase in body fat and the decline in lean mass and bone mineral density, to the development of disability. Two clinical centers, UTHSC (Memphis) and the University of Pittsburgh enrolled 3075 participants, aged 70-79, in Health ABC in 1997-98; participants were recruited primarily from a random sample of Medicare-eligible, community-dwelling persons living in the two communities. Eligibility criteria included self-reported ability to walk one-quarter of a mile and climb 10 steps without difficulty, self-reported ability to perform activities of daily living (ADLS) without difficulty, and no life-threatening cancer diagnosis. Follow-up included annual clinic or home visits (Year 1-6, 8, 10, 11, and 16) and semi-annual telephone visits. From Year 15-17 quarterly telephone visits including questions about end-of-life decision making were conducted with participants. Measurements of body composition, bone mineral density, strength, weight, cognitive function, pulmonary function as well as electrocardiography, various laboratory assessments, serum, plasma, DNA, and urine were obtained in clinic visits. Data collection also included questions on diet, depression, medications, ADLS, physical activity, social support, general health, and health events. Data collection and follow-up ended on 9/30/14. Contact Dr. Satterfield for more information or to inquire about potential collaborations and data analysis proposals. For online information, see www.grc.nia.nih.gov/branches/ledb/healthabc.

Air Force V: Prevention of Relapse in Participants Involuntary Abstinent From Tobacco
(PI - Bob Klesges, PhD)
Of smokers who receive a formal cessation program, at least 70% relapse; among self-quitters, the relapse rate is approximately 90%. Unfortunately, the vast majority of smokers who try to stop smoking do so with no or with minimal assistance. Brandon and colleagues have demonstrated that a series of 8 printed self-help booklets consistently produced higher point-prevalence abstinence rates in smokers that had quit on their own. Given the enormous public health implications of this approach, more research on promoting long-term self-quitting is clearly needed. However, nothing is known about methods of preventing relapse following involuntary abstinence (e.g., military training, during hospital stays, in jails, prisons, & psychiatric facilities). Previous research has determined that protracted involuntary cessation in the military with no other intervention is associated with significant long-term cessation rates (15-20% at a one-year follow-up). The aims of this study are to recruit approximately 5200 United States Air Force (USAF) recruits at the end of Basic Military Training (BMT) who were regular smokers prior to an 8-week involuntary cessation during BMT, to randomize participants either to (a) standard forced cessation, (b) forced cessation + printed materials (proven to be efficacious in previous studies among those who voluntarily quit on their own), and (c) forced cessation + 1 face to face meeting with Airmen before they have the opportunity to relapse. We will then determine long-term (12 month) efficacy of the cessation maintenance intervention. Our primary outcome is smoking cessation maintenance at 12 month follow-up. The secondary outcome is smoking cessation maintenance at 6 month follow-up.

Community Oncology Medical Home (COME HOME)
INACTIVE (PI - Teresa Waters, PhD)
The purpose of this project is to develop a model Community Oncology Medical Home to improve health outcomes, enhance patient care experiences and significantly reduce costs of care. We believe that this is possible by improving timeliness and coordination of care and by keeping patients out of the emergency department (ED) and hospital as much as possible. The target population for this project is newly diagnosed or relapsed Medicare, Medicaid and commercially insured patients seeking oncology care at one of 7 participating clinics. These patients require the wide range of coordinated care that COME HOME can deliver. The services to be delivered include all outpatient cancer care, including: triage pathways that ensure patients receive the right care in the right place at the right time for all aspects of cancer care, diagnostic pathways that address appropriate imaging, pathologic testing and molecular diagnostics, and therapeutic pathways delineating chemotherapy, radiation oncology, supportive care, and surgery (when applicable). The enhanced services offered under the COME HOME program include: patient education and medication management counseling, team care, 24/7 practice access (telephone triage, night/weekend clinic hours, and on-call oncologists), on-site or near-site imaging and laboratory testing, and admitting physicians who shepherd patients through inpatient encounters, avoiding handoffs and readmissions, to ensure seamless, safe and efficient care. Our outcomes analysis will focus on quality of care, outcomes and costs compared to other oncology practices.

Cardiovascular Disease/Hypertension/Hyperlipidemiaarrow Back to top

SPRINT Systolic Blood Pressure Intervention Trial
(PI, Memphis SPRINT site - Karen Johnson, MD, MPH; VA Clinical Center Network (CCN) PI - 25 VA sites nationwide, William Cushman, MD; VA CCN MIND PI, Linda O. Nichols, PhD)
SPRINT is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk in a population aged 50 and older who have high blood pressure but do not have either diabetes or have had a stroke. SPRINT MIND is examining the role of blood pressure in cognitive impairment. SPRINT is funded by the National Heart Lung and Blood Institute. If you are interested in this trial, call 901-448-8400 for more information or access our website at https://sprinttrial.org/public/dspHome.cfm. Veterans should call 901-523-8990, ext 6823 or check the website.

Look AHEAD (Action for Health in Diabetes)
(PI - Karen Johnson, MD, MPH)
Look AHEAD is a multicenter, randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. Look AHEAD has over 5,000 persons with type 2 diabetes participating at 16 centers and is funded by the National Institute of Diabetes, Digestive Disorders and Kidney Disease (NIDDK). For more information about the trial go to https://www.lookaheadtrial.org/public/home.cfm.

Look AHEAD in the Military (Action for Health in Diabetes)
The purpose of this project is (1) to translate and tailor the Look Ahead Intervention to the active duty U.S. Military population's lifestyle and environment that is unique to the military member; (2) to randomized participants to either the Look Ahead Intensive Lifestyle Intervention versus a Diet and Physical Activity Education condition (comparison group similar to the Diabetes Support and Education group in Look AHEAD). The Diet and Physical Activity Educaiton condition of this Look Ahead translation is not a placebo control group but an active information group that stresses nutrition, exercise and support (as in the original Look AHEAD trial).

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.

Health ABC (Health, Aging and Body Composition Study)
(PI - Suzanne Satterfield, M.D., Dr.P.H.)

The Health ABC Study is an observational, clinical research study funded by the National Institute on Aging in 1997. The study was designed to investigate the decline in function in healthier older persons and to relate changes in body composition in old age, particularly the increase in body fat and the decline in lean mass and bone mineral density, to the development of disability.
For a complete description

Caregivingarrow Back to top

Telephone Support During Overseas Deployment for Military Spouses - INACTIVE
Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression. This study, funded by the Department of Defense (DoD), Defense Health Program (DHP), managed by the US Army Medical Research and Materiel Command, Military Operational Medicine Research Program (MOMRP), will help spouses learn ways to manage stress and solve problems related to communication, managing long distance relationships, and other common deployment problems. The study will compare telephone support groups to online education sessions. Find information or volunteer at: vhamemsbm@va.gov, (901) 577-7485 or (800) 636-8262, ext. 7485, or www.memphis.va.gov/spousesupport

REACH VA Dementia (Resources for Enhancing All Caregivers Health in the VA)
(PI - Jennifer Martindale-Adams, EdD and Linda O. Nichols, PhD)
REACH VA is an award-winning, evidence-based program to assist stressed and burdened caregivers of Veterans with dementia or spinal cord injury/disease. Based on 16 years of research, REACH VA helps caregivers manage the patient's condition and their own stress from caregiving. REACH VA is a VA system-wide program, training staff at VA Medical Centers around the country, based at the Memphis VA Medical Center. For more information, email vhamemsbm@va.gov, or call (901) 577-7485 or (800) 636-8262, ext. 7485.

Children/Familiesarrow Back to top

CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood)
(PI = Fran Tylavsky, Dr.P.H.)
The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother's prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development from birth to three years of age. 1503 pregnant Shelby County mothers were recruited for this study, with the last baby being born in December of 2011.

Researchers seeking additional information please visit http://candlestudy.com/

CANDLE Study: Preschool Evaluation
(PI - Fran Tylavsky, Dr.P.H.)
The purpose of this study is to provide further information that will ultimately lead to improvements in the health, development and well-being of children in Shelby County. The primary goal of CANDLE Extended Follow-Up is to investigate the separate and combined effects of family interactions, the home environment, childhood experiences, exposure to potentially harmful toxins, the genetic make-up of the child on his/her development, and school readiness at age 4-5.

Researchers seeking additional information please visit http://candlestudy.com/

Genetic Investigationsarrow Back to top

CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood)
(PI = Fran Tylavsky, Dr.P.H.)
The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother's prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development from birth to three years of age. 1503 pregnant Shelby County mothers were recruited for this study, with the last baby being born in December of 2011.

Researchers seeking additional information please visit http://candlestudy.com/

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.

Health ABC (Health, Aging and Body Composition Study)
(PI - Suzanne Satterfield, M.D., Dr.P.H.)
The Health ABC Study is an observational, clinical research study funded by the National Institute on Aging in 1997. The study was designed to investigate the decline in function in healthier older persons and to relate changes in body composition in old age, particularly the increase in body fat and the decline in lean mass and bone mineral density, to the development of disability. Two clinical centers, UTHSC (Memphis) and the University of Pittsburgh enrolled 3075 participants, aged 70-79, in Health ABC in 1997-98; participants were recruited primarily from a random sample of Medicare-eligible, community-dwelling persons living in the two communities. Eligibility criteria included self-reported ability to walk one-quarter of a mile and climb 10 steps without difficulty, self-reported ability to perform activities of daily living (ADLS) without difficulty, and no life-threatening cancer diagnosis. Follow-up included annual clinic or home visits (Year 1-6, 8, 10, 11, and 16) and semi-annual telephone visits. From Year 15-17 quarterly telephone visits including questions about end-of-life decision making were conducted with participants. Measurements of body composition, bone mineral density, strength, weight, cognitive function, pulmonary function as well as electrocardiography, various laboratory assessments, serum, plasma, DNA, and urine were obtained in clinic visits. Data collection also included questions on diet, depression, medications, ADLS, physical activity, social support, general health, and health events. Data collection and follow-up ended on 9/30/14. Contact Dr. Satterfield for more information or to inquire about potential collaborations and data analysis proposals. For online information, see www.grc.nia.nih.gov/branches/ledb/healthabc.

Look AHEAD (Action for Health in Diabetes)
(PI - Karen Johnson, MD, MPH)
Look AHEAD is a multicenter, randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. Look AHEAD has over 5,000 persons with type 2 diabetes participating at 16 centers and is funded by the National Institute of Diabetes, Digestive Disorders and Kidney Disease (NIDDK). For more information about the trial go to https://www.lookaheadtrial.org/public/home.cfm.

SPRINT Systolic Blood Pressure Intervention Trial
(PI, Memphis SPRINT site - Karen Johnson, MD, MPH; VA Clinical Center Network (CCN) PI - 25 VA sites nationwide, William Cushman, MD; VA CCN MIND PI, Linda O. Nichols, PhD)
SPRINT is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk in a population aged 50 and older who have high blood pressure but do not have either diabetes or have had a stroke. SPRINT MIND is examining the role of blood pressure in cognitive impairment. SPRINT is funded by the National Heart Lung and Blood Institute. If you are interested in this trial, call 901-448-8400 for more information or access our website at https://sprinttrial.org/public/dspHome.cfm. Veterans should call 901-523-8990, ext 6823 or check the website.

Healthcare Financing/Policyarrow Back to top

Hospital Responses to Medicare's Nonpayment for Preventable Complications
INACTIVE (PI - Teresa Waters, PhD)
On October 1, 2008, Medicare implemented a new policy that denies incremental payment for eight preventable complications of medical care. Even though this CMS policy is limited in terms of involved conditions, hospital reaction may be substantial because this policy change is viewed by many as the first in a series of CMS payment reforms intended to increase its emphasis on value-based purchasing, using both positive incentives and negative penalties. Our study examines the impact of Medicare's new nonpayment rule on hospital behavior for four of the eight conditions identified by CMS as preventable. We are also assessing how hospital responses may vary depending on particular circumstances, such as hospital financial health and market conditions.

Community Oncology Medical Home (COME HOME)
INACTIVE (PI - Teresa Waters, PhD)
The purpose of this project is to develop a model Community Oncology Medical Home to improve health outcomes, enhance patient care experiences and significantly reduce costs of care. We believe that this is possible by improving timeliness and coordination of care and by keeping patients out of the emergency department (ED) and hospital as much as possible. The target population for this project is newly diagnosed or relapsed Medicare, Medicaid and commercially insured patients seeking oncology care at one of 7 participating clinics. These patients require the wide range of coordinated care that COME HOME can deliver. The services to be delivered include all outpatient cancer care, including: triage pathways that ensure patients receive the right care in the right place at the right time for all aspects of cancer care, diagnostic pathways that address appropriate imaging, pathologic testing and molecular diagnostics, and therapeutic pathways delineating chemotherapy, radiation oncology, supportive care, and surgery (when applicable). The enhanced services offered under the COME HOME program include: patient education and medication management counseling, team care, 24/7 practice access (telephone triage, night/weekend clinic hours, and on-call oncologists), on-site or near-site imaging and laboratory testing, and admitting physicians who shepherd patients through inpatient encounters, avoiding handoffs and readmissions, to ensure seamless, safe and efficient care. Our outcomes analysis will focus on quality of care, outcomes and costs compared to other oncology practices.

Military/VAarrow Back to top

Air Force V: Prevention of Relapse in Participants Involuntary Abstinent From Tobacco
(PI - Bob Klesges, PhD)
Of smokers who receive a formal cessation program, at least 70% relapse; among self-quitters, the relapse rate is approximately 90%. Unfortunately, the vast majority of smokers who try to stop smoking do so with no or with minimal assistance. Brandon and colleagues have demonstrated that a series of 8 printed self-help booklets consistently produced higher point-prevalence abstinence rates in smokers that had quit on their own. Given the enormous public health implications of this approach, more research on promoting long-term self-quitting is clearly needed. However, nothing is known about methods of preventing relapse following involuntary abstinence (e.g., military training, during hospital stays, in jails, prisons, & psychiatric facilities). Previous research has determined that protracted involuntary cessation in the military with no other intervention is associated with significant long-term cessation rates (15-20% at a one-year follow-up). The aims of this study are to recruit approximately 5200 United States Air Force (USAF) recruits at the end of Basic Military Training (BMT) who were regular smokers prior to an 8-week involuntary cessation during BMT, to randomize participants either to (a) standard forced cessation, (b) forced cessation + printed materials (proven to be efficacious in previous studies among those who voluntarily quit on their own), and (c) forced cessation + 1 face to face meeting with Airmen before they have the opportunity to relapse. We will then determine long-term (12 month) efficacy of the cessation maintenance intervention. Our primary outcome is smoking cessation maintenance at 12 month follow-up. The secondary outcome is smoking cessation maintenance at 6 month follow-up.

Air Force VI: Fit Blue (Dissemination of the Look Ahead Weight Management Treatment in the Military)
(PI - Bob Klesges, PhD)
This study will translate and tailor the Look Ahead weight loss intervention to the overweight/obese active duty U.S. Military populations, while accommodating the lifestyle and environment that is unique to military members and to evaluate the long term (one year) efficacy of the intervention in this population.

Air Force VII: Alcohol DoD (Prevention of Alcohol Related Incidents in the U.S. Air Force)
(PI - Bob Klesges, PhD)
This cluster randomized study has the goal of reducing the alcohol related incidents among US Airmen by testing the alcohol misconduct prevention program (AMPP) versus AMPP plus brief alcohol intervention (BAI) booster. It will also assess cost savings and long term effects of the booster intervention.

Air Force VIII: FREEDOM (Enhancing the Efficacy of a Tobacco Quit Line in the US Military)
(PI - Bob Klesges, PhD)
The goal of this grant is to measure the efficacy of military tobacco quit line by treating a sample of military personnel with proactive QL intervention followed by randomization of participants who relapse or fail to quit by the end of the proactive QL intervention to one of three conditions: (1) repeating the proactive QL (Recycle); (2) smoking reduction with the goal of eventual cessation (Rate Reduction); or (3) the choice of Recycle or Rate Reduction (Choice). Efficacy will be established by assessing both point prevalence and continuous abstinence at a one-year follow-up.

Air Force IX: New, Emerging and Traditional Tobacco Use in the Military
(PI - Bob Klesges, PhD)
The major goal of this study is to directly compare active duty personnel with National Guard/Reservists to gain greater knowledge about the frequency of non-daily use of traditional and new and emerging tobacco products. Also, to advance our understanding of the prevalence, incidence and diversity of tobacco product use in this population which will improve scientific knowledge and inform FDA tobacco regulatory decision-making.

SPRINT Systolic Blood Pressure Intervention Trial
(PI, Memphis SPRINT site - Karen Johnson, MD, MPH; VA Clinical Center Network (CCN) PI - 25 VA sites nationwide, William Cushman, MD; VA CCN MIND PI, Linda O. Nichols, PhD)
SPRINT is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk in a population aged 50 and older who have high blood pressure but do not have either diabetes or have had a stroke. SPRINT MIND is examining the role of blood pressure in cognitive impairment. SPRINT is funded by the National Heart Lung and Blood Institute. If you are interested in this trial, call 901-448-8400 for more information or access our website at https://sprinttrial.org/public/dspHome.cfm. Veterans should call 901-523-8990, ext 6823 or check the website.

REACH VA Dementia (Resources for Enhancing All Caregivers Health in the VA)
(PI - Jennifer Martindale-Adams, EdD and Linda O. Nichols, PhD)
REACH VA is an award-winning, evidence-based program to assist stressed and burdened caregivers of Veterans with dementia or spinal cord injury/disease. Based on 16 years of research, REACH VA helps caregivers manage the patient's condition and their own stress from caregiving. REACH VA is a VA system-wide program, training staff at VA Medical Centers around the country, based at the Memphis VA Medical Center. For more information, email vhamemsbm@va.gov, or call (901) 577-7485 or (800) 636-8262, ext. 7485.

Telephone Support During Overseas Deployment for Military Spouses - INACTIVE
Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression. This study, funded by the Department of Defense (DoD), Defense Health Program (DHP), managed by the US Army Medical Research and Materiel Command, Military Operational Medicine Research Program (MOMRP), will help spouses learn ways to manage stress and solve problems related to communication, managing long distance relationships, and other common deployment problems. The study will compare telephone support groups to online education sessions. Find information or volunteer at: vhamemsbm@va.gov, (901) 577-7485 or (800) 636-8262, ext. 7485, or www.memphis.va.gov/spousesupport

Look AHEAD in the Military (Action for Health in Diabetes)
The purpose of this project is (1) to translate and tailor the Look Ahead Intervention to the active duty U.S. Military population's lifestyle and environment that is unique to the military member; (2) to randomized participants to either the Look Ahead Intensive Lifestyle Intervention versus a Diet and Physical Activity Education condition (comparison group similar to the Diabetes Support and Education group in Look AHEAD). The Diet and Physical Activity Educaiton condition of this Look Ahead translation is not a placebo control group but an active information group that stresses nutrition, exercise and support (as in the original Look AHEAD trial).

Neurocognitive Developmentarrow Back to top

CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood)
(PI = Fran Tylavsky, Dr.P.H.)
The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother's prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development from birth to three years of age. 1503 pregnant Shelby County mothers were recruited for this study, with the last baby being born in December of 2011.

Researchers seeking additional information please visit http://candlestudy.com/

Obesity/Weight Loss/Dietarrow Back to top

CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood)
(PI = Fran Tylavsky, Dr.P.H.)
The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother's prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development from birth to three years of age. 1503 pregnant Shelby County mothers were recruited for this study, with the last baby being born in December of 2011.

Researchers seeking additional information please visit http://candlestudy.com/

Look AHEAD (Action for Health in Diabetes)
(PI - Karen Johnson, MD, MPH)
Look AHEAD is a multicenter, randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. Look AHEAD has over 5,000 persons with type 2 diabetes participating at 16 centers and is funded by the National Institute of Diabetes, Digestive Disorders and Kidney Disease (NIDDK). For more information about the trial go to https://www.lookaheadtrial.org/public/home.cfm.

Look AHEAD in the Military (Action for Health in Diabetes)
The purpose of this project is (1) to translate and tailor the Look Ahead Intervention to the active duty U.S. Military population's lifestyle and environment that is unique to the military member; (2) to randomized participants to either the Look Ahead Intensive Lifestyle Intervention versus a Diet and Physical Activity Education condition (comparison group similar to the Diabetes Support and Education group in Look AHEAD). The Diet and Physical Activity Educaiton condition of this Look Ahead translation is not a placebo control group but an active information group that stresses nutrition, exercise and support (as in the original Look AHEAD trial).

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.

Smoking Cessationarrow Back to top

Air Force V: Prevention of Relapse in Participants Involuntary Abstinent From Tobacco
(PI - Bob Klesges, PhD)
Of smokers who receive a formal cessation program, at least 70% relapse; among self-quitters, the relapse rate is approximately 90%. Unfortunately, the vast majority of smokers who try to stop smoking do so with no or with minimal assistance. Brandon and colleagues have demonstrated that a series of 8 printed self-help booklets consistently produced higher point-prevalence abstinence rates in smokers that had quit on their own. Given the enormous public health implications of this approach, more research on promoting long-term self-quitting is clearly needed. However, nothing is known about methods of preventing relapse following involuntary abstinence (e.g., military training, during hospital stays, in jails, prisons, & psychiatric facilities). Previous research has determined that protracted involuntary cessation in the military with no other intervention is associated with significant long-term cessation rates (15-20% at a one-year follow-up). The aims of this study are to recruit approximately 5200 United States Air Force (USAF) recruits at the end of Basic Military Training (BMT) who were regular smokers prior to an 8-week involuntary cessation during BMT, to randomize participants either to (a) standard forced cessation, (b) forced cessation + printed materials (proven to be efficacious in previous studies among those who voluntarily quit on their own), and (c) forced cessation + 1 face to face meeting with Airmen before they have the opportunity to relapse. We will then determine long-term (12 month) efficacy of the cessation maintenance intervention. Our primary outcome is smoking cessation maintenance at 12 month follow-up. The secondary outcome is smoking cessation maintenance at 6 month follow-up.

TARGIT (Treating Adults at Risk for Weight Gain with Interactive Technology)
(PI - Karen Johnson, MD, MPH)
Cross-Study Analysis of Coordinated Randomized Clinical Trials for Weight Management. This is a follow up study to develop and test a behavioral weight loss/weight gain prevention intervention delivered through interactive technology.

SNRTQ-PACE (Strategies to Promote Cessation in Smokers Who are Not to Quit)
(PI - Bob Klesges, PhD)
This study is: (1) To test a tobacco Quit Line for Smokers not ready to quit (SNRTQ); (2) To randomize 2100 SNRTQs to: (3) To evaluate the efficacy of the intervention. The primary endpoint will be point prevalence at the 6-month post-intervention follow-up (12 months after randomization); and; (4) To determine the cost effectiveness (cost per quit smoker) of each of the interventions.

Violence/Domestic Violencearrow Back to top

Post Coital DNA Recovery Project
(Project Evaluator - Pam Connor, PhD)
This project is designed to provide evidence to support or limit the expansion of the 72-hour time frame for evidence collection from the vagina and cervix after a rape event in adult females. In most jurisdictions, post-coital samples are collected up to, but not after, 72 hours following rape.

Reducing Domestic Violence, Dating Violence, Sexual Assault, and Stalking on Campus Program
(PI - Pam Connor, PhD)
This project is sponsored by the U.S. Department of Justice Office of Violence Against Women initiative and is designed to educate the UTHSC campus community, as well as build strong partnerships and lasting collaborations with both campus and community organizations, in order to respond to and help prevent and reduce campus violence.

Women/Women's Healtharrow Back to top

Post Coital DNA Recovery Project
(Project Evaluator - Pam Connor, PhD)
This project is designed to provide evidence to support or limit the expansion of the 72-hour time frame for evidence collection from the vagina and cervix after a rape event in adult females. In most jurisdictions, post-coital samples are collected up to, but not after, 72 hours following rape.

Reducing Domestic Violence, Dating Violence, Sexual Assault, and Stalking on Campus Program
(PI - Pam Connor, PhD)
This project is sponsored by the U.S. Department of Justice Office of Violence Against Women initiative and is designed to educate the UTHSC campus community, as well as build strong partnerships and lasting collaborations with both campus and community organizations, in order to respond to and help prevent and reduce campus violence.

Telephone Support During Overseas Deployment for Military Spouses - INACTIVE
Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression. This study, funded by the Department of Defense (DoD), Defense Health Program (DHP), managed by the US Army Medical Research and Materiel Command, Military Operational Medicine Research Program (MOMRP), will help spouses learn ways to manage stress and solve problems related to communication, managing long distance relationships, and other common deployment problems. The study will compare telephone support groups to online education sessions. Find information or volunteer at: vhamemsbm@va.gov, (901) 577-7485 or (800) 636-8262, ext. 7485, or www.memphis.va.gov/spousesupport

WHI (Women's Health Initiative)
(PI - Karen Johnson, MD, MPH)
The Women's Health Initiative (WHI) is a multi-center, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. This 15-year project involves 161,808 women aged 50-79, and is one of the most definitive, far-reaching clinical trials and observational studies of post-menopausal women's health ever undertaken in the U.S. The Department of Preventive Medicine at the UTHSC is one of 40 WHI sites across the U.S. The WHI is funded by the National Heart Lung and Blood Institute (NHLBI). For additional information on the WHI study, please visit the study website at www.whiscience.org.