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Volunteer for a Research Study

The Department of Preventive Medicine conducts observational research studies and clinical trials.

Observational Research – studies that collect data and samples from patients in order to examine patterns of disease, risk factors and outcomes over a period of time.
Clinical Trials – studies that test whether a medical or behavioral treatment is safe and effective to use in a particular group of people.

 
Planning A Change Easily (PACE)

logoVirtually all smoking cessation interventions have been conducted on the small percentage of smokers who indicate a willingness to quit smoking. Much less well-studied are approaches for assisting the smokers who are not ready to quit smoking at the current time (ex., not in the next 30 days). There have been two different approaches towards increasing cessation rates in smokers not ready to quit. The first approach is Motivational Interviewing using “5Rs”as a foundation (Relevance, Risks, Rewards, Roadblocks, Repetition). The second approach combines behavioral/pharmacological rate reduction as an approach to produce reductions in tobacco use. The current National Cancer Institute funded (1R01CA193245-01A1) study examines the comparative effectiveness of Motivational Interviewing, Rate Reduction, and their combination in a large sample (N = 828) of smokers not ready to quit. This design allows us to evaluate the independent and additive effects of Motivational Interviewing and Rate Reduction on quit attempts and smoking cessation. The primary endpoint will be point prevalence at the 6-month post-intervention follow-up (12 months after randomization). A second aim is to determine the cost effectiveness (cost per quit smoker) of each of the interventions.

Website: https://www.pacestudy.org/


Fit & Quit Study

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Ideally, there would be programs that do not require people to choose between quitting smoking and gaining 10 pounds (on average). We are developing just such a program! 

Participants will try one of 3 different weight management strategies. In addition, all participants will receive the same 6 session phone-based smoking cessation program and 6 months of Chantix at no cost. In addition to treatment at no cost, participants may earn up to $100 for completing all aspects of the study. For further information, please see: https://www.fitandquit.org/.  Call today to see if you qualify—901-448-2000


Systolic Blood Pressure Intervention Trial – Alzheimer’s, Senior, Kidney (SPRINT ASK)

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Why Is This Study Being Done? – There is evidence that high blood pressure can cause changes in memory and thinking as people get older.  When the SPRINT study intervention was stopped in September of 2015, important data on long term rate of Alzheimer’s, change in cognition, and impact on the kidneys were not able to be collected.  Participants from the SPRINT study will undergo a single SPRINT ASK visit approximately two years after their SPRINT closeout visit to assess blood pressure, cognitive and kidney function. For further information, please see: https://www.sprinttrial.org/public/dspHome.cfm.


Conditions Affecting Neurocognitive Development and Learning in Early Childhood


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CANDLE is an observational cohort research study of the development of children from birth to age eleven. The CANDLE study has enrolled 1503 healthy pregnant women in Shelby County between 2006-2011. The study name "CANDLE" stands for Conditions Affecting Neurocognitive Development and Learning in Early Childhood. The long term objective of this study is to provide information that will ultimately lead to improvements in the health, development, and well-being of children in Shelby County, TN through interventions and policy enforcement and/or development. The primary goal of CANDLE is to investigate the separate and combined effects of the mother’s prenatal actions, the home environment and childhood experiences, the exposure to potentially harmful toxins, and the genetic make-up of the child on his/her brain development and health from birth to age eleven. CANDLE is currently conducting study visits with 8-11 year-olds in an effort to assess the association between stress, genetics, and environmental exposures on both cognitive development and lung health in middle childhood. Website: https://candlestudy.uthsc.edu/


Environmental Influences on Child Health Outcomes

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CANDLE is part of the NIH funded Environmental Influences on Child Health Outcomes (ECHO) program. ECHO was designed to fund existing pediatric cohorts with a goal of enrolling more than 50,000 children from diverse racial, geographic and socioeconomic backgrounds to become part of the ECHO consortium. These cohort studies will analyze existing data as well as follow the children over time to address the early environmental origins of at least one of ECHO’s health outcome areas. Each cohort will participate with the others to combine data that are collected in a standardized way across the consortium. The CANDLE cohort, along with two partner cohorts, has now become part of the ECHO consortium, and the current study activities will be combined with those of studies across the United States to further our understanding of health and development in childhood.

 

Last Published: May 10, 2018