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UT INVESTIGATOR WINS GRANT TO STUDY CARDIAC REGULATION
Could Lead to New Treatments for Heart Failure
Memphis, Tennessee (August 19, 2005) – Rennolds Ostrom, PhD, assistant professor in the Department of Pharmacology and the Vascular Biology Center of Excellence, has been awarded a $154,000 two-year grant by the American Heart Association (Southeast Affiliate).
“Both beat-to-beat and long-term cardiac function is regulated, in part, by an intracellular messenger (cAMP). My lab has found that certain enzymes, which are responsible for synthesizing this messenger, have very distinct locations inside heart muscle cells. Altering the specific cellular location of these enzymes may improve cardiac function in the event of heart failure,” explained Dr. Ostrom. His research mission is to understand the structural basis of these enzymes’s subcellular location, create hybrid proteins with altered localization, and determine how these new enzymes affect cardiac function.
Ostrom completed his PhD in pharmacology and
toxicology at the
This study quantifies the economic impact of the UTHSC on the economy of the state of Tennessee for FY2010.
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