Victor V. Chizhikov, PhD

Victor V. Chizhikov, Ph.D.

Associate Professor
Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center

The University of Tennessee Health Science Center
855 Monroe Ave, Link Building, Ste 515
Memphis, TN 38163
Phone: (901) 448-2309
Fax: (901) 448-7193
Lab: 528 Johnson Building
Email: Victor V. Chizhikov



  • PhD Institution: NN Blokhin Cancer Research Center, Moscow, Russia
  • Postdoctoral: University of Chicago, Department of Human Genetics, Chicago, IL

Research Interests

Our laboratory has two goals: (1) to identify the molecular mechanisms that regulate the development of the mammalian brain and (2) to define the pathogenic mechanisms that underlie human developmental brain disorders. Specifically, we focus on two dorsal brain regions - the developing cerebellum and the cerebral cortex. The cerebellum is a major center of motor-coordination and is also involved in certain cognitive functions. The cerebral cortex is responsible for higher brain functions such as learning, memory and perception. Developmental abnormalities of the cerebellum and cerebral cortex are relatively frequent in human patients and are associated with autism, intellectual disability and hydrocephalus. In our laboratory we use the following approaches and techniques: analysis of knockout and transgenic mice, genetic fate mapping, in utero electroporation, explants, laser capture microdissection, in situ hybridization RNA-seq, and immunohistochemistry.

Representative Publications

  • Glover JC, Elliott KL, Erives A, Chizhikov VV, Fritzsch B. Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution. Dev Biol. 2018 Feb 12. pii: S0012-1606(17)30584-5. doi: 10.1016/j.ydbio.2018.02.001. [Epub ahead of print] Review. PubMed PMID: 29447907.
  • Iskusnykh IY, Steshina EY, Chizhikov VV. Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710. doi: 10.1523/JNEUROSCI.2526-15.2016. PubMed PMID: 26937009; PubMed Central PMCID: PMC4879213.
  • Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, Segura-Wang M, Waszak SM, Jones DT, Kool M, Hovestadt V, Buchhalter I, Sieber L, Johann P, Chavez L, Gröschel S, Ryzhova M, Korshunov A, Chen W, Chizhikov VV, Millen KJ, Amstislavskiy V, Lehrach H, Yaspo ML, Eils R, Lichter P, Korbel JO, Pfister SM, Bradner JE, Northcott PA. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 2016 Feb 4;530(7588):57-62. doi: 10.1038/nature16546. Epub 2016 Jan 27. PubMed PMID: 26814967; PubMed Central PMCID: PMC5168934.
  • Shih EK, Sekerková G, Ohtsuki G, Aldinger KA, Chizhikov VV, Hansel C, Mugnaini E, Millen KJ. The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype. Cerebellum. 2015 Jun;14(3):292-307. doi: 10.1007/s12311-014-0640-x. PubMed PMID: 25626522; PubMed Central PMCID: PMC4832921.
  • Haldipur P, Gillies GS, Janson OK, Chizhikov VV, Mithal DS, Miller RJ, Millen KJ. Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth. Elife. 2014 Dec 16;3. doi: 10.7554/eLife.03962. PubMed PMID: 25513817; PubMed Central PMCID: PMC4281880.
  • Choudhri AF, Sable HJ, Chizhikov VV, Buddington KK, Buddington RK. Parenteral nutrition compromises neurodevelopment of preterm pigs. J Nutr. 2014 Dec;144(12):1920-7. doi: 10.3945/jn.114.197145. Epub 2014 Oct 23. PubMed PMID: 25342697.

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