JIANXIONG JIANG, Ph.D.


Jianxiong Jiang, PhDAssociate Professor
Department of Pharmaceutical Sciences
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center

The University of Tennessee Health Science Center
665 College of Pharmacy Building
881 Madison Avenue
Memphis, TN 38163
Phone: (901) 448-2935
Fax: (901) 448-4731
Email: Jianxiong Jiang

 

 

Education

  • Ph.D. Institution: Auburn University, Auburn, AL
  • Postdoctoral: Emory University, Atlanta, GA

Links

Research Interests

The research in our laboratory is primarily dedicated to a better understanding of neuroinflammatory processes following brain insults such as prolonged seizures. We have also recently begun to explore the neuron-glia interactions in malignant gliomas, the most devastating brain tumors that constitute a major cause for epilepsy, particularly in the elderly. We attempt to unlock the cellular and molecular mechanisms whereby normal brains are transformed to generate spontaneous recurrent seizures, i.e., acquired epileptogenesis. We are also interested in developing novel antiepileptic and/or antiepileptogenic therapeutics in close collaboration with medicinal chemistry laboratories. To achieve these goals, we use a variety of technologies and experimental systems, such as high-throughput screening, chemical genetics, TR-FRET, RNAi, CRISPR/Cas9, microdialysis, time-locked video EEG, behavioral tests, etc.

Representative Publications

  • Jiang J, Yu Y, Kinjo ER, Du Y, Nguyen HP, Dingledine R. Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury. Neuropharmacology. 2019 May 1;149:149-160. doi: 10.1016/j.neuropharm.2019.02.011. Epub 2019 Feb 11. PubMed PMID: 30763657; PubMed Central PMCID: PMC6486887.
  • Qiu J, Li Q, Bell KA, Yao X, Du Y, Zhang E, Yu JJ, Yu Y, Shi Z, Jiang J. Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. Br J Pharmacol. 2019 Jun;176(11):1680-1699. doi: 10.1111/bph.14622. Epub 2019 Apr 29. PubMed PMID: 30761522; PubMed Central PMCID: PMC6514294.
  • Jiang J, Van TM, Ganesh T, Dingledine R. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. doi: 10.1021/acschemneuro.7b00486. Epub 2018 Jan 4. PubMed PMID: 29292987; PubMed Central PMCID: PMC6318807.
  • Hartings JA, York J, Carroll CP, Hinzman JM, Mahoney E, Krueger B, Winkler MKL, Major S, Horst V, Jahnke P, Woitzik J, Kola V, Du Y, Hagen M, Jiang J, Dreier JP. Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction. Brain. 2017 Oct 1;140(10):2673-2690. doi: 10.1093/brain/awx214. PubMed PMID: 28969382; PubMed Central PMCID: PMC5841026.
  • Kang X, Qiu J, Li Q, Bell KA, Du Y, Jung DW, Lee JY, Hao J, Jiang J. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. doi: 10.1038/s41598-017-09528-z. PubMed PMID: 28842681; PubMed Central PMCID: PMC5573328.
  • Jiang J, Qiu J, Li Q, Shi Z. Prostaglandin E2 Signaling: Alternative Target for Glioblastoma? Trends Cancer. 2017 Feb;3(2):75-78. doi: 10.1016/j.trecan.2016.12.002. Epub 2017 Jan 11. Review. PubMed PMID: 28718447; PubMed Central PMCID: PMC5518646.

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