Bob M. Moore II, Ph.D.

Bob M. Moore II, Ph.D.

Professor


Department of Pharmaceutical Sciences


The University of Tennessee Health Science Center
874 Union Avenue, Room 327D
Memphis, TN 38163
Tel: (901) 448-6085
Fax: (508) 448-6828
Email: Bob M. Moore



Education

  • B.S. in Chemistry, Indiana State University, 1983
  • M.S. in Chemistry, Indiana State University, 1989
  • Ph.D. (Medicinal Chemistry), University of Kansas, 1995

Research Interests

Research in Dr. Moore's lab integrates synthetic organic chemistry, computational chemistry and biological assays aimed at developing new chemotherapeutic entities. The current areas of research include:

  1. Development of cannabinoid receptor (CB1 and CB2) agonist and antagonist.
  2. Development of novel therapies for combat causality care with emphasis on hemorrhagic shock and hemostasis.
  3. Development of GPRC directed anti-neoplastic agents.
  4. Combination drug therapies for the treatment of sepsis, stroke and ischemic brain conditions.

Representative Publications

  • Abidi AH, Presley CS, Dabbous M, Tipton DA, Mustafa SM, Moore BM 2nd. Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts. Arch Oral Biol. 2017 Dec 6;87:79-85. doi: 10.1016/j.archoralbio.2017.12.005. [Epub ahead of print] PubMed PMID: 29274621.
  • Pressly JD, Mustafa SM, Abidi A, Alghamdi S, Pandey P, Roy KK, Doerksen R, Moore BM, Park F. Selective cannabinoid 2 receptor stimulation reduces tubular epithelial cell damage following renal ischemia-reperfusion injury. J Pharmacol Exp Ther. 2017 Nov 29. pii: jpet.117.245522. doi: 10.1124/jpet.117.245522. [Epub ahead of print] PubMed PMID: 29187590.
  • Liu Y, McAfee SS, Guley NM, Del Mar N, Bu W, Heldt SA, Honig MG, Moore BM 2nd, Reiner A, Heck DH. Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189. eNeuro. 2017 Aug 18;4(4). pii: ENEURO.0387-16.2017. doi: 10.1523/ENEURO.0387-16.2017. eCollection 2017 Jul-Aug. PubMed PMID: 28828401; PubMed Central PMCID: PMC5562300.
  • Moore BM, Ng HKB, Naoum C, Simmons L, Cartwright BL, Wilson MK, Ng MKC. Transcatheter Mitral Valve Replacement With a Novel Dual Stent Bioprosthesis. Circ Cardiovasc Interv. 2017 Jun;10(6). pii: e004841. doi: 10.1161/CIRCINTERVENTIONS.116.004841. PubMed PMID: 28566291.
  • Moore BM, Adams JT, Barakatt E. Outcomes Following a Vestibular Rehabilitation and Aerobic Training Program to Address Persistent Post-Concussion Symptoms. J Allied Health. 2016 Winter;45(4):e59-e68. PubMed PMID: 27915363.
  • Cochran BJ, Hou L, Manavalan AP, Moore BM, Tabet F, Sultana A, Cuesta Torres L, Tang S, Shrestha S, Senanayake P, Patel M, Ryder WJ, Bongers A, Maraninchi M, Wasinger VC, Westerterp M, Tall AR, Barter PJ, Rye KA. Erratum. Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism. Diabetes 2016;65:3610-3620. Diabetes. 2017 Feb;66(2):560. doi: 10.2337/db17-er02b. Epub 2016 Dec 1. PubMed PMID: 27908917; PubMed Central PMCID: PMC5248998.

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