Peter J McKinnon, Ph.D.

Peter J McKinnon, Ph.D.

Department of Genetics and Tumor
Cell Biology
St. Jude Children's Research Hospital

Affiliated Professor
Department of Anatomy and Neurobiology


St. Jude Children's Research Hospital
Department Genetics & Tumor Cell Biology
262 Danny Thomas Place
Memphis, TN 38105
Phone (901) 595-2700
Fax (901) 525-6035
Email: Peter J McKinnon



Education

  • Ph.D. Institution: The Flinders Universiry of South Australia, Adelaide, Australia
  • Postdoctoral: The Roche Institute of Molecular Biology, Nutley, New Jersey

Link

Research Interests

Our goal is to understand the role of the DNA damage response in the nervous system, and how this functions to prevent disease. The response to genotoxic stress is a prerequisite for development of the nervous system. Mutations in a variety of DNA damage-response factors can lead to human diseases that are characterized by pronounced neuropathology. In many of these syndromes the neurological component is amongst the most deleterious aspects of the disease. Because the nervous system poses a particular challenge in terms of clinical intervention, understanding how DNA repair deficiency impacts the nervous system will be important for design of therapies targeted at ameliorating neuropathology including neurodegeneration and brain tumors. For more information please see: http://www.stjude.org/mckinnon

Representative Publications

  • Binder M, Chmielarz P, Mckinnon PJ, Biggs LC, Thesleff I, Balic A. Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche. Stem Cells. 2019 May 30. doi: 10.1002/stem.3042. [Epub ahead of print] PubMed PMID: 31145830.
  • Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression. Cancer Cell. 2019 Jan 14;35(1):140-155.e7. doi: 10.1016/j.ccell.2018.11.015. Epub 2018 Dec 27. PubMed PMID: 30595505; PubMed Central PMCID: PMC6570409.
  • Lavado A, Park JY, Paré J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018 Dec 3;47(5):576-591.e8. doi: 10.1016/j.devcel.2018.09.021. Epub 2018 Oct 25. PubMed PMID: 30523785; PubMed Central PMCID: PMC6296252.
  • Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ. Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294. doi: 10.1073/pnas.1809682115. Epub 2018 Dec 11. PubMed PMID: 30538199; PubMed Central PMCID: PMC6310806.
  • Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4. PubMed PMID: 30420702; PubMed Central PMCID: PMC6232171.
  • ElInati E, Russell HR, Ojarikre OA, Sangrithi M, Hirota T, de Rooij DG, McKinnon PJ, Turner JMA. DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12536-12541. doi: 10.1073/pnas.1712530114. Epub 2017 Nov 7. PubMed PMID: 29114052; PubMed Central PMCID: PMC5703310.

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