Massroor Pourcyrous, MD

Education

• M.D. Institution: Tabriz University School of Medicine, Tabriz, Iran
• Residency: Pediatrics, University of Tabriz, Farman-Farmaian Children's Hospital, Tabriz, Iran; Pediatrics, Louisiana State University Charity Hospital and Children's Hospital, New Orleans, LA
• Fellowship: Neonatal-Perinatal Medicine, Departments of Pediatrics and Obstetrics and Gynecology, UTHSC; Post-doctoral Fellow in Neonatal Physiology, Department of Physiology and Biophysics, UTHSC

Research Interests

My interest has been in Translational Research in area of hemodynamics of cerebral circulation in newborn pigs and in human neonates during physiologic and pathologic conditions such as asphyxia/reventilation, seizures and intraventricular hemorrhage.

I have also investigated cerebrovascular manifestations of illicit drug (cocaine) and licit drugs that are used in neonates (sympathomimetics, indomethacin, anticonvulsants, sildenafil, partial liquid ventilation..).

Also, investigating for Biomarkers have been other part of my research interests: C-reactive protein in neonatal infection and other neonatal disorders; Fecal short chain fatty acids as a predictor of GI disorders; Cerebral spinal fluid cAMP as a predictor of neurological outcome in asphyxiated neonates; and clinical implications of brain-derived circulating endothelial cells.

Representative Publications

• Rana D, Pollard L, Rowland J, Dhanireddy R, Pourcyrous M. Amplitude-integrated EEG in infants with neonatal abstinence syndrome. J Neonatal Perinatal Med. 2019 Jul 22. doi: 10.3233/NPM-1834. [Epub ahead of print] PubMed PMID: 31356218.
• Patel S, Fedinec AL, Liu J, Weiss MA, Pourcyrous M, Harsono M, Parfenova H, Leffler CW. H(2)S mediates the vasodilator effect of endothelin-1 in the cerebral circulation. Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1759-H1764. doi: 10.1152/ajpheart.00451.2018. Epub 2018 Sep 28. PubMed PMID: 30265150; PubMed Central PMCID: PMC6336977.
• Parfenova H, Pourcyrous M, Fedinec AL, Liu J, Basuroy S, Leffler CW. Astrocyte-produced carbon monoxide and the carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by prolonged neonatal asphyxia. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H978-H988. doi: 10.1152/ajpheart.00140.2018. Epub 2018 Jul 20. PubMed PMID: 30028198; PubMed Central PMCID: PMC6230909.
• Pourcyrous M, Chilakala S, Elabiad MT, Parfenova H, Leffler CW. Does prolonged severe hypercapnia interfere with normal cerebrovascular function in piglets? Pediatr Res. 2018 Aug;84(2):290-295. doi: 10.1038/s41390-018-0061-5. Epub 2018 May 28. PubMed PMID: 29907849; PubMed Central PMCID: PMC6185793.
• Liu J, Pourcyrous M, Fedinec AL, Leffler CW, Parfenova H. Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter? Pediatr Res. 2017 Nov;82(5):881-887. doi: 10.1038/pr.2017.152. Epub 2017 Aug 16. PubMed PMID: 28665933; PubMed Central PMCID: PMC5645245.
• Harsono M, Pourcyrous M, Jolly EJ, de Jongh Curry A, Fedinec AL, Liu J, Basuroy S, Zhuang D, Leffler CW, Parfenova H. Selective head cooling during neonatal seizures prevents postictal cerebral vascular dysfunction without reducing epileptiform activity. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1202-H1213. doi: 10.1152/ajpheart.00227.2016. Epub 2016 Sep 2. PubMed PMID: 27591217; PubMed Central PMCID: PMC5130497.

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