James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Mudigoudar B, Wheless JW. Response to Correspondence on "A Better Understanding of Brain Involvement in 22q11.2 Deletion Syndrome". Pediatr Neurol. 2018 Jan;78:e7. doi: 10.1016/j.pediatrneurol.2017.10.009. Epub 2017 Oct 12. PubMed PMID: 29174003.
  • Mudigoudar B, Nune S, Fulton S, Dayyat E, Wheless JW. Epilepsy in 22q11.2 Deletion Syndrome: A Case Series and Literature Review. Pediatr Neurol. 2017 Nov;76:86-90. doi: 10.1016/j.pediatrneurol.2017.08.011. Epub 2017 Aug 26. PubMed PMID: 28969878.
  • Wheless JW. Safety of Supratherapeutic Doses of Newer Antiepileptic Drugs in Children: What Have We Really Learned? J Pediatr Pharmacol Ther. 2017 Jul-Aug;22(4):244-245. doi: 10.5863/1551-6776-22.4.244. PubMed PMID: 28943816; PubMed Central PMCID: PMC5562201.
  • Papanicolaou AC, Wheless JW, Babajani-Feremi A, Narayana S, Rezaie R, Choudhri A, Boop F. Letter re: Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 Aug 8;89(6):640. doi: 10.1212/WNL.0000000000004204. PubMed PMID: 28784636.
  • Elahian B, Yeasin M, Mudigoudar B, Wheless JW, Babajani-Feremi A. Identifying seizure onset zone from electrocorticographic recordings: A machine learning approach based on phase locking value. Seizure. 2017 Oct;51:35-42. doi: 10.1016/j.seizure.2017.07.010. Epub 2017 Jul 25. PubMed PMID: 28772200.
  • Papanicolaou AC, Rezaie R, Narayana S, Choudhri AF, Abbas-Babajani-Feremi, Boop FA, Wheless JW. On the relative merits of invasive and non-invasive pre-surgical brain mapping: New tools in ablative epilepsy surgery. Epilepsy Res. 2017 Jul 3. pii: S0920-1211(17)30232-2. doi: 10.1016/j.eplepsyres.2017.07.002. [Epub ahead of print] PubMed PMID: 28716297.

View more references (pubmed link)