Edward Chaum, M.D., Ph.D.

Edward Chaum, M.D., Ph.D.

Acting Director of Research

Plough Foundation Professor of Retinal Diseases
Hamilton Eye Institute
Department of Ophthalmology

Department of Pediatrics
Department of Anatomy and Neurobiology
Department of Biomedical Engineering

The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Avenue, Suite 731
Memphis, TN 38163
Tel: (901) 448-5975
Email: Edward Chaum



  • Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
  • M.D. Institution: Cornell University Medical College


Ophthalmology - Edward Chaum

Research Interests

The focus of the basic science research program in our laboratory is in five major areas:

  • Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
  • Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
  • Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
  • Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
  • Tele-ophthalmology and automated diagnostics

Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:

  • Genomic analysis of RPE gene expression,
  • The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
  • The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
  • Electrochemical quantification of blood metabolites and drugs, and
  • Nanotechnology applications in retinal surgery, and
  • Clinical research studies.

Representative Publications

  • Bhattacharya S, Gangaraju R, Chaum E. Recent Advances in Retinal Stem Cell Therapy. Curr Mol Biol Rep. 2017 Sep;3(3):172-182. doi: 10.1007/s40610-017-0069-3. Epub 2017 Jul 10. PubMed PMID: 29152454; PubMed Central PMCID: PMC5685516.
  • Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, Ziegler G, Cleary PA, Brunzell JD; DCCT/EDIC Research Group. Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes Care. 2017 Dec;40(12):1756-1762. doi: 10.2337/dc16-2523. PubMed PMID: 29138273; PubMed Central PMCID: PMC5711332.
  • Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162. PubMed PMID: 28437526; PubMed Central PMCID: PMC5403116.
  • DCCT/EDIC Research Group, Nathan DM, Bebu I, Hainsworth D, Klein R, Tamborlane W, Lorenzi G, Gubitosi-Klug R, Lachin JM. Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes. N Engl J Med. 2017 Apr 20;376(16):1507-1516. doi: 10.1056/NEJMoa1612836. PubMed PMID: 28423305; PubMed Central PMCID: PMC5557280.
  • Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J. Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells. J Cancer. 2017 Jan 1;8(1):57-64. doi: 10.7150/jca.16723. eCollection 2017. PubMed PMID: 28123598; PubMed Central PMCID: PMC5264040.
  • Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Yates CR. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91(1):1-13. Epub 2016 Nov 9. Erratum in: Mol Pharmacol. 2017 Dec;92 (6):627. PubMed PMID: 27913654.

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