Edward Chaum, M.D., Ph.D.


Edward Chaum, M.D., Ph.D.

Acting Director of Research

Plough Foundation Professor of Retinal Diseases
Hamilton Eye Institute
Department of Ophthalmology


Department of Pediatrics
Department of Anatomy and Neurobiology
Department of Biomedical Engineering


The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Avenue, Suite 731
Memphis, TN 38163
Tel: (901) 448-5975
Email: Edward Chaum

 

Education

  • Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
  • M.D. Institution: Cornell University Medical College

Link

Ophthalmology - Edward Chaum

Research Interests

The focus of the basic science research program in our laboratory is in five major areas:

  • Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
  • Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
  • Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
  • Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
  • Tele-ophthalmology and automated diagnostics

Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:

  • Genomic analysis of RPE gene expression,
  • The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
  • The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
  • Electrochemical quantification of blood metabolites and drugs, and
  • Nanotechnology applications in retinal surgery, and
  • Clinical research studies.

Representative Publications

  • Yu JJ, Agrón E, Clemons TE, Domalpally A, van Asten F, Keenan TD, Cukras C, Chew EY; Age-Related Eye Disease Study 2 Research Group. Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17. Ophthalmology. 2018 Aug 22. pii: S0161-6420(18)31752-4. doi: 10.1016/j.ophtha.2018.08.017. [Epub ahead of print] PubMed PMID: 30142373.
  • Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, Danis RG, Sadda S, Rosenfeld PJ, Klein ML, Ratnapriya R, Swaroop A, Ferris FL 3rd, Chew EY; AREDS2 Research Group. Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16. Ophthalmology. 2018 Jul 27. pii: S0161-6420(18)30875-3. doi: 10.1016/j.ophtha.2018.05.028. [Epub ahead of print] PubMed PMID: 30060980.
  • Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J. Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway. Biochem Biophys Res Commun. 2018 Apr 6;498(3):573-578. doi: 10.1016/j.bbrc.2018.03.021. Epub 2018 Mar 6. PubMed PMID: 29522718; PubMed Central PMCID: PMC5920696.
  • Bhattacharya S, Gangaraju R, Chaum E. Recent Advances in Retinal Stem Cell Therapy. Curr Mol Biol Rep. 2017 Sep;3(3):172-182. doi: 10.1007/s40610-017-0069-3. Epub 2017 Jul 10. PubMed PMID: 29152454; PubMed Central PMCID: PMC5685516.
  • Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, Ziegler G, Cleary PA, Brunzell JD; DCCT/EDIC Research Group. Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes Care. 2017 Dec;40(12):1756-1762. doi: 10.2337/dc16-2523. PubMed PMID: 29138273; PubMed Central PMCID: PMC5711332.
  • Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162. PubMed PMID: 28437526; PubMed Central PMCID: PMC5403116.

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