Microbiology, Immunology and Biochemistry Faculty
Member, Department of Immunology, St. Jude Children's Research Hospital
Research Interests: JNK and p38 MAP kinase (MAPK) pathway in innate and adaptive immunity; Sphingosine 1-phosphate (S1P) pathway in T cell trafficking and immune responses; molecular mechanisms of immune-mediated disorders including infectious and autoimmune diseases.
Van Vleet Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Eukaryotic genome-wide transcription regulatory networks and cell biology of transcriptional regulation.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Regulation of the endocytosis and intracellular trafficking of membrane transporters, and the role of the cytoskeleton in these processes.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Understanding the mechanisms by which alveolar macrophage activation and polarization contributes to lung pathology during chronic hypersensitivity pneumonitis.
Member, Department of Pathology
Research Interests: Regulation of T-cell responses in and immunotherapy for autoimmune diseases.
Assistant Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Oral vaccines based in commensal bacteria for prevention and treatment of microbial and allergen induced diseases. Reservoir targeted vaccine for the control of Lyme borreliosis.
Member, Department of Genetics/Tumor Cell Biology
Research Interests: Biosynthesis of proteins in the secretory pathway; Signal transduction pathways that are activated by cellular stress.
Member, Department of Infectious Disease
Research Interests: Roles of phospholipid synthesis in cellular functions; Regulation of coenzyme A as a determinant of metabolic switching.
Member, Department of Structural Biology
No research interests at this time
Member, Department of Chemical Biology and Therapeutics, SJCRH
Research Interests: Novel approaches to antimicrobial drug discovery, and drug mechanism of action and resistance studies.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Virus-host cell interactions during infections of hepatitis C virus and related viruses; innate immune signaling mechanisms to viral infections.
Assistant Member, Dept. of Immunology
Research Interests: Our research is focused on the molecular and cellular regulation of T cells during infectious disease and autoimmune disease.
Assistant Member, Department of Structural Biology
Research Interests: Biophysical and functional characterization of the role of multiple degrons in substrate recognition by ubiquitin ligases; the role of 'fuzzy' complexes in signal transduction and ubiquitination.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Bioinformatics and evolution of the cytochrome P450 superfamily; Molecular history of eukaryotic life.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Role of matrix metalloproteinases in glioma and arthritis; Targeting glioma by anti-MMP inhibitors.
Associate Professor, Department of Microbiology, Immunology and Biochemistry
Research Interests: Molecular analysis of autoantibody structure and characterization of autoantigens that elicit autoimmune responses.
Associate Professor, Department of Pharmacy, LeBonheur Children's Medical Center
Research Interests: Antifungal action and resistance in the pathogenic fungi Candida albicans and Candida glabrata; Host innate immune response to Candida albicans and Candida glabrata.
Professor, Department of Medicine and Pathology
Research Interests: Role of the MHC class II molecules, T cells, and cytokines in susceptibility to autoimmune arthritis.
Associate Member, Department of Infectious Diseases, St. Jude Children's Research Hospital
Research Interests: Molecular mechanisms of paramyxovirus entry and pathogenesis; development of vaccines against paramyxovirus infection; structure-based design of inhibitors against paramyxovirus replication.
Member, Dept. of Infectious Diseases
Stacey.Schultz-Cherry@stjude.org
Research Interests: Pathogenesis of RNA viruses; specifically influenza and astroviruses. We are interested in the viral-host interactions at the epithelial and innate immune cell level. Our studies encompass a wide range of disciplines including virology, cell biology, and molecular biology. A new area of study in the laboratory is the impact of obesity on influenza virus pathogenesis and therapeutic strategies. We also have several on-going surveillance projects that would expose interested students to virology at the public health interface.
Paul Thomas, PhD
Associate Member, Department of Immunology, SJCRH
Research Interests: My research program is focused on understanding how innate and adaptive immunity determine the outcome of influenza A virus infection in humans and in the mouse model. Over the last few years, we have discovered determinants of pathogenicity among viral strains, characterized the interface of the virus with the host epithelial cell and recruited innate response, and measured the relative contributions of viral- and immune-induced pathology to morbidity and mortality. I continue to pursue a robust program in adaptive immunity, including studies of T cell repertoire and the regulation of T cell receptor expression during viral infection. The regulatory effects on T cell biology by innate host response pathways have important consequences for viral clearance and immunopathology.
Research Interests: Molecular mechanisms of pneumococcal invasion using in vivo and in vitro models of pneumonia, sepsis, and meningitis.
Member, Department of Infectious Diseases
Research Interests: Reverse genetics technologies to improve influenza vaccines, as well as to understand the pathogenesis of, and immune response to, influenza viruses
Member, Department of Infectious Disease
Research Interests: The origin and control of pandemic influenza viruses.
Professor and Chair, Department of Microbiology, Immunology and Biochemistry
Research Interests: Molecular basis of negative-strand virus entry, replication, and assembly; Development of cell-specific cytolytic and oncolytic vectors; Molecular mechanisms of viral oncolysis with emphasis on glioblastoma multiformae.
Associate Professor, Department of Pediatrics and Molecular Sciences
Research Interests: Research focuses on identifying new signaling components in host pattern recognition Eeceptor and signaling pathways that amplify or attenuate pro-inflammatory responses during the course of infection and autoimmue process.